Arat Maden Eda, Altun Ceyhan, Açikel Cengizhan
Oral Health Prev Dent. 2017;15(2):117-121. doi: 10.3290/j.ohpd.a37973.
The present prospective, randomised, placebo-controlled, clinical trial was designed to evaluate the clinical effects of a commercially available dentifrice containing fluoride, xylitol or xylitol-probiotic on the decrease of plaque and gingival inflammation in children between 13 and 15 years of age.
Forty-eight adolescents were randomly grouped into three groups of n = 16 each: study group A received xylitol (Xyliwhite) toothpaste; study group B received xylitol-probiotic (Periobiotic) toothpaste; and the control group C received fluoride (Colgate Max Fresh) toothpaste. The subjects were instructed to use the dentifrice determined and a modified Bass brushing technique twice a day for two minutes over a 6-week perioed. Clinical evaluation was performed using a gingival index and a plaque index at baseline and at the end of the 6-week period.
From day 0 to 42, reductions in the plaque index were statistically significant in all groups, Colgate Max Fresh, PerioBiotic and Xyliwhite (p-values 0.001, 0.001 and 0.035, respectively), but reductions in the gingival index were statistically significant only in the Colgate Max Fresh and PerioBiotic groups (both with p = 0.001), not in the Xyliwhite group (p = 0.116). PerioBiotic toothpaste was found to be better than Xyliwhite and Colgate Max Fresh toothpastes at reducing plaque and gingival scores. However, statistically significant differences with PerioBiotic and Colgate Max Fresh toothpaste were not observed.
It was concluded that PerioBiotic was an all-round dentifrice that produced a significant reduction in both gingivitis and plaque.
本前瞻性、随机、安慰剂对照临床试验旨在评估一种市售含氟、木糖醇或木糖醇-益生菌牙膏对13至15岁儿童牙菌斑减少和牙龈炎症的临床效果。
48名青少年被随机分为三组，每组n = 16：研究组A使用木糖醇（Xyliwhite）牙膏；研究组B使用木糖醇-益生菌（Periobiotic）牙膏；对照组C使用含氟（高露洁劲爽）牙膏。受试者被指示使用指定牙膏，并采用改良巴氏刷牙法，每天两次，每次两分钟，为期6周。在基线和6周结束时，使用牙龈指数和菌斑指数进行临床评估。
从第0天到第42天，所有组（高露洁劲爽、PerioBiotic和Xyliwhite）的菌斑指数均有统计学显著下降（p值分别为0.001、0.001和0.035），但牙龈指数仅在高露洁劲爽组和PerioBiotic组有统计学显著下降（p均 = 0.001），Xyliwhite组无显著下降（p = 0.116）。发现PerioBiotic牙膏在降低菌斑和牙龈分数方面优于Xyliwhite牙膏和高露洁劲爽牙膏。然而，与PerioBiotic牙膏和高露洁劲爽牙膏相比，未观察到统计学显著差异。
得出结论，PerioBiotic是一种全方位牙膏，能显著降低牙龈炎和牙菌斑。
