Maden E A, Altun C, Ozmen B, Basak F
Department of Pediatric Dentistry, Center of Oral and Dental Health, Gumussuyu Military Hospital, Istanbul, Turkey.
Department of Pediatric Dentistry, Center of Dental Sciences, Gulhane Medical Academy, Ankara, Turkey.
Niger J Clin Pract. 2018 Feb;21(2):134-138. doi: 10.4103/njcp.njcp_320_16.
This in vivo study was designed to compare the antimicrobial effect of toothpastes containing fluoride, xylitol, or xylitol-probiotic on Streptococcus mutans and Lactobacillus in 13-15-year-old children.
The study consisted of 60 pediatric patients who were randomly divided into three groups of 20 each. Group 1 recieved fluoride toothpaste (Colgate Max Fresh), group 2 used xylitol toothpaste (Xyliwhite), and group 3 used xylitol-probiotic toothpaste (PerioBiotic). Participants were asked to use the allocated dentifrice two times a day for 6 weeks. We performed tests on the saliva samples at the beginning of the study and after 6 weeks' duration following the use of toothpaste. The Statistical Package for the Social Sciences version 15 software and chi-square test were used for data analysis.
PerioBiotic toothpaste and Colgate Max Fresh toothpaste showed significant reduction in the number of participants who, prior to commencing the study, were diagnosed with a high number of cariogenic bacteria. On the contrary, no significant changes were observed with respect to the number of participants with a very high number of S. mutans and Lactobacillus on Xyliwhite toothpaste group.
In the light of the data obtained in this in-vivo study, a new innovational aspect has been reached in the use of probiotics to ensure the balance between bacterial flora in the oral cavity. In daily routine, the administration of probiotics to children is difficult. The toothpaste can be used as a vehicle to transport probiotics to children's mouth.
本体内研究旨在比较含氟牙膏、木糖醇牙膏或木糖醇-益生菌牙膏对13 - 15岁儿童口腔中变形链球菌和乳酸杆菌的抗菌效果。
该研究包括60名儿科患者，随机分为三组，每组20人。第一组使用含氟牙膏（高露洁劲爽清新牙膏），第二组使用木糖醇牙膏（Xyliwhite），第三组使用木糖醇-益生菌牙膏（PerioBiotic）。参与者被要求每天使用指定牙膏两次，持续6周。在研究开始时以及使用牙膏6周后，我们对唾液样本进行了检测。使用社会科学统计软件包第15版软件和卡方检验进行数据分析。
PerioBiotic牙膏和高露洁劲爽清新牙膏显示，在研究开始前被诊断为含有大量致龋菌的参与者数量显著减少。相反，在使用Xyliwhite牙膏组中，变形链球菌和乳酸杆菌数量非常高的参与者数量没有观察到显著变化。
根据本体内研究获得的数据，在使用益生菌以确保口腔细菌菌群平衡方面达成了一个新的创新点。在日常生活中，给儿童施用益生菌很困难。牙膏可作为将益生菌输送到儿童口腔的载体。
