Zhang Chen, Patil Rahul S, Li Tao, Barnes Charles L, Atwood Jerry L
Department of Chemistry, University of Missouri-Columbia, 601 S College Ave, Columbia, MO 65211, USA.
Chem Commun (Camb). 2017 Apr 13;53(31):4312-4314. doi: 10.1039/c7cc01208j.
The solvothermal synthesis of a metal-seamed hexameric nanocapsule from pyrogallol[4]arenes and magnesium is reported. The unique non-toxic and biocompatible nature of divalent magnesium cations in addition to the large inherent cavities make these nanocapsules promising for potential application in biomedicine. In addition, we show that these nanocapsules can form cocrystals with pyridine molecules through hydrogen bonding, which sheds light to cocrystallization of supramolecular nanocapsules with small pharmaceutics.
报道了由连苯三酚[4]芳烃和镁通过溶剂热合成法制备金属缝合六聚体纳米胶囊。除了具有较大的固有空腔外，二价镁阳离子独特的无毒和生物相容性使其在生物医药领域具有潜在的应用前景。此外，我们还表明，这些纳米胶囊可以通过氢键与吡啶分子形成共晶体，这为超分子纳米胶囊与小药物分子的共结晶提供了思路。
