Sikligar Kanishka, Kelley Steven P, Wagle Durgesh V, Ishtaweera Piyuni, Baker Gary A, Atwood Jerry L
Department of Chemistry, University of Missouri - Columbia 601 S College Avenue Columbia MO - 65211 USA
Department of Chemistry and Physics, Florida Gulf Coast University 10501 FGCU Blvd. S. Fort Myers FL - 33965 USA.
Chem Sci. 2023 Jul 3;14(34):9063-9067. doi: 10.1039/d3sc01629c. eCollection 2023 Aug 30.
The inception of an unprecedented class of voluminous Platonic solids displaying hierarchical geometry based on pyrogallol[4]arene moieties seamed by divalent calcium ion is described. Single-crystal X-ray structural determination has established the highly conserved geometry of two original Ca-seamed nanocapsules to be essentially cubic in shape with -ethylpyrogallol[4]arene units located along the twelve edges of the cube which are then bridged by metallic polyatomic cations ([CaCl] or [Ca(HCO)Na]) at the six cube faces. The accessible volume of the nanocapsules is 3500 Å and 2500 Å and is completely isolated from the exterior of the capsules. These remarkable nanocapsule discoveries cast a spotlight on a marginalized area of synthetic materials chemistry and encourage future exploration of diversiform supramolecular assemblies, networks, and capsules built on calcium, with clear benefits deriving from the intrinsic biocompatibility of calcium. Finally, a proof-of-concept is demonstrated for fluorescent reporter encapsulation and sustained release from the calcium-seamed nanocapsules, suggesting their potential as delivery vehicles for drugs, nutrients, preservatives, or antioxidants.
描述了一类前所未有的大量柏拉图立体的诞生，这些立体基于由二价钙离子缝合的连苯三酚[4]芳烃部分呈现出分层几何结构。单晶X射线结构测定确定了两个原始钙缝合纳米胶囊的高度保守几何形状基本上为立方体，其中 - 乙基连苯三酚[4]芳烃单元沿着立方体的十二条边排列，然后在六个立方体面上由金属多原子阳离子（[CaCl]或[Ca(HCO)Na]）桥接。纳米胶囊的可及体积分别为3500 Å和2500 Å，并且与胶囊外部完全隔离。这些非凡的纳米胶囊发现聚焦于合成材料化学的一个边缘领域，并鼓励未来对基于钙构建的各种超分子组装体、网络和胶囊进行探索，钙的固有生物相容性具有明显益处。最后，展示了荧光报告分子封装在钙缝合纳米胶囊中并持续释放的概念验证，表明它们作为药物、营养物质、防腐剂或抗氧化剂递送载体的潜力。
