关于自我报告的过敏与免疫球蛋白E浓度关系的全表观基因组DNA甲基化研究。
Epigenome-wide DNA methylation study of IgE concentration in relation to self-reported allergies.
作者信息
Ek Weronica E, Ahsan Muhammad, Rask-Andersen Mathias, Liang Liming, Moffatt Miriam F, Gyllensten Ulf, Johansson Åsa
机构信息
Department of Immunology, Genetics & Pathology, Science for Life Laboratory, Uppsala University, Box 815 75108 Uppsala, Sweden.
Department of Epidemiology & Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
出版信息
Epigenomics. 2017 Apr;9(4):407-418. doi: 10.2217/epi-2016-0158. Epub 2017 Mar 21.
AIM
Epigenetic mechanisms are critical for normal immune development and epigenetic alterations might therefore be possible contributors to immune diseases. To investigate if DNA methylation in whole blood is associated with total and allergen-specific IgE levels.
METHODS
We performed an epigenome-wide association study to investigate the association between DNA methylation and IgE level, allergen-specific IgE and self-reported immune diseases and allergies in 728 individuals.
RESULTS
We identified and replicated 15 CpG sites associated with IgE, mapping to biologically relevant genes, including ACOT7, ILR5A, KCNH2, PRG2 and EPX. A total of 331 loci were associated with allergen-specific IgE, but none of these CpG sites were associated with self-reported allergies and immune diseases.
CONCLUSION
This study shows that IgE levels are associated with DNA methylation levels at numerous CpG sites, which might provide new leads for investigating the links between IgE and allergic inflammation.
目的
表观遗传机制对正常免疫发育至关重要，因此表观遗传改变可能是免疫疾病的潜在促成因素。旨在研究全血中的DNA甲基化是否与总IgE水平及过敏原特异性IgE水平相关。
方法
我们进行了一项全表观基因组关联研究，以调查728名个体中DNA甲基化与IgE水平、过敏原特异性IgE以及自我报告的免疫疾病和过敏之间的关联。
结果
我们鉴定并重复验证了15个与IgE相关的CpG位点，这些位点映射到具有生物学相关性的基因，包括ACOT7、ILR5A、KCNH2、PRG2和EPX。共有331个基因座与过敏原特异性IgE相关，但这些CpG位点均与自我报告的过敏和免疫疾病无关。
结论
本研究表明，IgE水平与众多CpG位点的DNA甲基化水平相关，这可能为研究IgE与过敏性炎症之间的联系提供新线索。
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