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营养表观基因组学、个性化营养与食物过敏管理中的临床实践的相互作用

The Interplay of Nutriepigenomics, Personalized Nutrition and Clinical Practice in Managing Food Allergy.

作者信息

Ali Adli, Hamzaid Nur Hana, Ismail Noor Akmal Shareela

机构信息

Department of Pediatrics, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.

Dietetic Program & Centre for Rehabilitation and Special Needs Studies (iCaRehab), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.

出版信息

Life (Basel). 2021 Nov 22;11(11):1275. doi: 10.3390/life11111275.

Abstract

Food allergy in children has been a common issue due to the challenges of prescribing personalized nutrition with a lack of nutriepigenomics data. This has indeed further influenced clinical practice for appropriate management. While allergen avoidance is still the main principle in food allergy management, we require more information to advance the science behind nutrition, genes, and the immune system. Many researchers have highlighted the importance of personalized nutrition but there is a lack of data on how the decision is made. Thus, this review highlights the relationship among these key players in identifying the solution to the clinical management of food allergy with current nutriepigenomics data. The discussion integrates various inputs, including clinical assessments, biomarkers, and epigenetic information pertaining to food allergy, to curate a holistic and personalized approach to food allergy management in particular.

摘要

由于缺乏营养表观基因组学数据,在为儿童开具个性化营养处方时面临挑战,儿童食物过敏一直是个常见问题。这确实进一步影响了适当管理的临床实践。虽然避免接触过敏原仍是食物过敏管理的主要原则,但我们需要更多信息来推动营养、基因和免疫系统背后的科学发展。许多研究人员强调了个性化营养的重要性,但缺乏关于如何做出决策的数据。因此,本综述强调了这些关键因素之间的关系,以利用当前的营养表观基因组学数据确定食物过敏临床管理的解决方案。讨论整合了各种信息,包括临床评估、生物标志物以及与食物过敏相关的表观遗传信息,以制定一种全面且个性化的食物过敏管理方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f1b/8623511/725bb2dc189b/life-11-01275-g001.jpg

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