Oldenburg Reid, Demangel Caroline
Institut Pasteur, Unité d'Immunobiologie de l'Infection, Paris, France; INSERM U1221, Paris, France; Université Paris Diderot, Sorbonne Paris-Cité, Paris, France.
Institut Pasteur, Unité d'Immunobiologie de l'Infection, Paris, France; INSERM U1221, Paris, France.
Biochimie. 2017 Oct;141:3-8. doi: 10.1016/j.biochi.2017.03.012. Epub 2017 Mar 18.
Phenolic glycolipids (PGL) are polyketide synthase products that are uniquely produced by a subset of pathogenic mycobacteria and are displayed at the bacterial cell surface, in a strategic position to interfere with host immune cells. Their expression has been associated with enhanced mycobacterial virulence in vivo, and suppression of the inflammatory responses of host phagocytes in vitro. In this review, we will present our current understanding of the mode of operation of PGL, along with functional evidence that demonstrates the evolutionary advantage conferred by PGL production for host cell invasion, intracellular persistence and evasion of host immune and bactericidal responses.
酚糖脂（PGL）是聚酮合酶的产物，由致病性分枝杆菌的一个亚群独特产生，并展示在细菌细胞表面，处于干扰宿主免疫细胞的关键位置。它们的表达与体内分枝杆菌毒力增强以及体外宿主吞噬细胞炎症反应的抑制有关。在这篇综述中，我们将阐述目前对PGL作用方式的理解，以及功能证据，这些证据证明了PGL产生对于宿主细胞入侵、细胞内存活以及逃避宿主免疫和杀菌反应所赋予的进化优势。
