Ambrosi B, Bochicchio D, Colombo P, Ferrario R, Faglia G
Chair of Endocrinology, University of Milano, Italy.
Horm Metab Res Suppl. 1987;16:74-5.
The effect of loperamide - a peripheral opiate agonist - on plasma ACTH response to Corticotropin-releasing Hormone (CRH) has been investigated in 6 patients with Addison's disease. After placebo administration CRH induced a marked ACTH increase. After loperamide administration ACTH levels fell to a nadir of 135 +/- 76 pg/ml, and then CRH was still able to induce an ACTH increase; the pattern of ACTH response to CRH was slightly delayed. There was a significant difference between the two ACTH curves after CRH only in the early phase of the response. These data suggest that the inhibitory role of loperamide on ACTH secretion is exerted at supra-pituitary level, although a pituitary site of action can not be excluded.
已对6例艾迪生病患者研究了外周阿片受体激动剂洛哌丁胺对血浆促肾上腺皮质激素（ACTH）对促肾上腺皮质激素释放激素（CRH）反应的影响。给予安慰剂后，CRH可使ACTH显著升高。给予洛哌丁胺后，ACTH水平降至最低点135±76 pg/ml，然后CRH仍能使ACTH升高；ACTH对CRH的反应模式略有延迟。仅在反应的早期阶段，CRH后的两条ACTH曲线之间存在显著差异。这些数据表明，洛哌丁胺对ACTH分泌的抑制作用是在垂体以上水平发挥的，尽管不能排除垂体作用位点。
