Pirich K, Vierhapper H, Nowotny P, Waldhäusl W
Exp Clin Endocrinol. 1986 Jul;87(2):208-10. doi: 10.1055/s-0029-1210545.
To investigate the possibility that the prolonged administration of corticotropin releasing factor (CRF) might suppress rather than enhance pituitary ACTH-secretion 24-hour infusions (50 micrograms/h) of ovine CRF were performed in 6 patients with adrenocortical insufficiency. CRF induced a heterogeneous behaviour of plasma ACTH concentrations in these hypercorticotropinemic patients but both a sustained increase and a suppression of ACTH was clearly absent at the end of the 24 hour infusion period. Thus, continuous administration of CRF does not appear to be a promising way to control abundance of plasma ACTH concentrations in patients with Addison's disease.
为了研究长期给予促肾上腺皮质激素释放因子（CRF）可能抑制而非增强垂体促肾上腺皮质激素（ACTH）分泌的可能性，对6例肾上腺皮质功能不全患者进行了24小时静脉输注（50微克/小时）羊CRF的试验。在这些促肾上腺皮质激素水平升高的患者中，CRF引起了血浆ACTH浓度的异质性变化，但在24小时输注期结束时，ACTH既没有持续升高，也没有受到抑制。因此，持续给予CRF似乎不是控制Addison病患者血浆ACTH浓度过高的有效方法。
