Bruno Davide, Nierenberg Jay, Cooper Thomas B, Marmar Charles R, Zetterberg Henrik, Blennow Kaj, Hashimoto Kenji, Pomara Nunzio
School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, UK.
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA; Department of Psychiatry, School of Medicine, New York University, New York City, NY, USA.
Neurobiol Learn Mem. 2017 May;141:14-18. doi: 10.1016/j.nlm.2017.03.011. Epub 2017 Mar 18.
Glutamate is the principal excitatory neurotransmitter in the central nervous system, and is thought to be involved in the process of memory encoding and storage. Glutamate disturbances have also been reported in psychiatric disorders, such as schizophrenia and major depressive disorder (MDD), and in Alzheimer's disease. In this paper, we set out to study the relationship between cerebrospinal fluid (CSF) glutamate levels and memory performance, which we believe has not been reported previously. In particular, we focused on recall performance broken down by serial position. Our prediction was that the recency ratio (Rr), a novel cognitive marker of intellectual impairment, would be linked with CSF glutamate levels. We studied data from a group of cognitively intact elderly individuals, 28 of whom had MDD, while 19 were controls. Study results indicated that Rr levels, but no other memory score, were inversely correlated with CSF glutamate levels, although this was found only in individuals with late-life MDD. For comparison, glutamine or GABA were not correlated with any memory performance measure.
谷氨酸是中枢神经系统中主要的兴奋性神经递质，被认为参与记忆编码和存储过程。据报道，在精神疾病如精神分裂症和重度抑郁症（MDD）以及阿尔茨海默病中也存在谷氨酸紊乱。在本文中，我们着手研究脑脊液（CSF）谷氨酸水平与记忆表现之间的关系，我们认为此前尚未有相关报道。特别是，我们关注按序列位置分解的回忆表现。我们的预测是，新近度比率（Rr），一种智力障碍的新型认知标志物，将与脑脊液谷氨酸水平相关。我们研究了一组认知功能正常的老年人的数据，其中28人患有MDD，19人作为对照。研究结果表明，Rr水平而非其他记忆分数与脑脊液谷氨酸水平呈负相关，不过这仅在患有晚年MDD的个体中发现。作为比较，谷氨酰胺或γ-氨基丁酸与任何记忆表现指标均无关联。
