Guan Joseph, Li Guohua
All of the authors are with the Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY. Guohua Li is also with the Department of Anesthesiology, Columbia University College of Physicians & Surgeons, New York.
Am J Public Health. 2017 May;107(5):791-793. doi: 10.2105/AJPH.2017.303696. Epub 2017 Mar 21.
To examine epidemiological patterns of injury fatalities in individuals with a diagnosis of autism.
We identified individuals with a diagnosis of autism who died between 1999 and 2014 by screening causes of death in the multiple cause-of-death data files in the National Vital Statistics System based on the International Classification of Diseases, 10th Revision, code F84.0. We used the general US population as the reference to calculate proportionate mortality ratios (PMRs) and 95% confidence intervals (CIs).
During the study period, 1367 deaths (1043 males and 324 females) in individuals with autism were recorded in the United States. The mean age at death for individuals with autism was 36.2 years (SD = 20.9 years), compared with 72.0 years (SD = 19.2 years) for the general population. Of the deaths in individuals with autism, 381 (27.9%) were attributed to injury (PMR = 2.93; 95% CI = 2.64, 3.24), with suffocation (n = 90; PMR = 31.93; 95% CI = 25.69, 39.24) being the leading cause of injury mortality, followed by asphyxiation (n = 78; PMR = 13.50; 95% CI = 10.68, 16.85) and drowning (n = 74; PMR = 39.89; 95% CI = 31.34, 50.06).
Individuals with autism appear to be at substantially heightened risk for death from injury.
研究诊断为自闭症的个体的伤害致死的流行病学模式。
我们通过在国家生命统计系统的多重死因数据文件中,根据国际疾病分类第十版代码F84.0筛查死因,确定了1999年至2014年间死亡的自闭症患者。我们以美国普通人群作为参考,计算比例死亡率(PMR)和95%置信区间(CI)。
在研究期间,美国记录了1367例自闭症患者死亡(1043例男性和324例女性)。自闭症患者的平均死亡年龄为36.2岁(标准差=20.9岁),而普通人群为72.0岁(标准差=19.2岁)。在自闭症患者的死亡中,381例(27.9%)归因于伤害(PMR=2.93;95%CI=2.64,3.24),其中窒息(n=90;PMR=31.93;95%CI=25.69,39.24)是伤害致死的主要原因,其次是窒息(n=78;PMR=13.50;95%CI=10.68,16.85)和溺水(n=74;PMR=39.89;95%CI=31.34,50.06)。
自闭症患者似乎因伤害而死亡的风险大幅增加。