McGee-Lawrence Meghan E, Wenger Karl H, Misra Sudipta, Davis Catherine L, Pollock Norman K, Elsalanty Mohammed, Ding Kehong, Isales Carlos M, Hamrick Mark W, Wosiski-Kuhn Marlena, Arounleut Phonepasong, Mattson Mark P, Cutler Roy G, Yu Jack C, Stranahan Alexis M
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
Department of Orthopedic Surgery, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
Endocrinology. 2017 May 1;158(5):1160-1171. doi: 10.1210/en.2016-1250.
Whole-body vibration (WBV) has gained attention as a potential exercise mimetic, but direct comparisons with the metabolic effects of exercise are scarce. To determine whether WBV recapitulates the metabolic and osteogenic effects of physical activity, we exposed male wild-type (WT) and leptin receptor-deficient (db/db) mice to daily treadmill exercise (TE) or WBV for 3 months. Body weights were analyzed and compared with WT and db/db mice that remained sedentary. Glucose and insulin tolerance testing revealed comparable attenuation of hyperglycemia and insulin resistance in db/db mice following TE or WBV. Both interventions reduced body weight in db/db mice and normalized muscle fiber diameter. TE or WBV also attenuated adipocyte hypertrophy in visceral adipose tissue and reduced hepatic lipid content in db/db mice. Although the effects of leptin receptor deficiency on cortical bone structure were not eliminated by either intervention, exercise and WBV increased circulating levels of osteocalcin in db/db mice. In the context of increased serum osteocalcin, the modest effects of TE and WBV on bone geometry, mineralization, and biomechanics may reflect subtle increases in osteoblast activity in multiple areas of the skeleton. Taken together, these observations indicate that WBV recapitulates the effects of exercise on metabolism in type 2 diabetes.
全身振动（WBV）作为一种潜在的运动模拟方式已受到关注，但与运动代谢效应的直接比较却很少。为了确定WBV是否能重现体育活动的代谢和成骨效应，我们将雄性野生型（WT）和瘦素受体缺陷型（db/db）小鼠每天进行跑步机运动（TE）或WBV，持续3个月。分析体重并与久坐不动的WT和db/db小鼠进行比较。葡萄糖和胰岛素耐受性测试显示，TE或WBV后db/db小鼠的高血糖和胰岛素抵抗得到了类似程度的减轻。两种干预措施均降低了db/db小鼠的体重并使肌纤维直径恢复正常。TE或WBV还减轻了内脏脂肪组织中的脂肪细胞肥大，并降低了db/db小鼠的肝脏脂质含量。尽管两种干预措施均未消除瘦素受体缺乏对皮质骨结构的影响，但运动和WBV增加了db/db小鼠骨钙素的循环水平。在血清骨钙素升高的情况下，TE和WBV对骨几何形态、矿化和生物力学的适度影响可能反映了骨骼多个区域成骨细胞活性的细微增加。综上所述，这些观察结果表明WBV重现了运动对2型糖尿病代谢的影响。
