Wang Linhao, Wang Jie, Tan Yewei, Cai Changyu, Yang Xiaohua, Dong Sashuang, Hong Jiaqi, Fang Xiang, Wei Hong, Liao Zhenlin
College of Food Science, South China Agricultural University, Guangzhou 510642, China.
College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Nutrients. 2025 Jun 23;17(13):2081. doi: 10.3390/nu17132081.
: Probiotics have recently emerged as promising agents in the prevention and treatment of various human diseases. This study investigates the therapeutic potential of SA9 in the management of type 2 diabetes mellitus (T2DM). : The in vitro antidiabetic activity of SA9 was primarily assessed via its α-glucosidase inhibitory capacity, complemented by metabolomic profiling to identify putative bioactive metabolites. The antidiabetic efficacy was further evaluated in a db/db mouse model, focusing on glucose tolerance, inflammatory biomarkers, and gut microbiota composition. : SA9 showed significant inhibitory effects on α-glucosidase and α-amylase, and DNJ and other active substances were detected in its culture supernatant. After 6 weeks of continuous administration, the fasting blood glucose level, glucose tolerance, and inflammation indexes of mice were significantly improved. Beneficial changes in the structure of the intestinal flora occurred after the probiotic intervention, as evidenced by a significant decrease in harmful bacteria (e.g., ) and a significant enrichment of beneficial bacteria (e.g., ). : SA9 exerts robust antidiabetic effects and holds promise as a novel strategy for the prevention and management of T2DM.
益生菌最近已成为预防和治疗各种人类疾病的有前景的药物。本研究调查了SA9在2型糖尿病（T2DM）管理中的治疗潜力。：SA9的体外抗糖尿病活性主要通过其α-葡萄糖苷酶抑制能力进行评估，并辅以代谢组学分析以鉴定假定的生物活性代谢物。在db/db小鼠模型中进一步评估抗糖尿病疗效，重点关注葡萄糖耐量、炎症生物标志物和肠道微生物群组成。：SA9对α-葡萄糖苷酶和α-淀粉酶显示出显著的抑制作用，并且在其培养上清液中检测到DNJ和其他活性物质。连续给药6周后，小鼠的空腹血糖水平、葡萄糖耐量和炎症指标显著改善。益生菌干预后肠道菌群结构发生有益变化，有害细菌（如）显著减少和有益细菌（如）显著富集证明了这一点。：SA9发挥强大的抗糖尿病作用，并有望成为预防和管理T2DM的新策略。
