Joung Kyoung Eun, Cataltepe Sule Umit, Michael Zoe, Christou Helen, Mantzoros Christos S
Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115.
Harvard Medical School, Boston, Massachusetts 02115.
J Clin Endocrinol Metab. 2017 May 1;102(5):1606-1613. doi: 10.1210/jc.2016-3831.
Infants born small for gestational age (SGA) have increased risk for obesity and metabolic syndrome, but the underlying mechanisms are not fully elucidated. Adipocyte fatty acid-binding protein (AFABP) is an adipokine that has been implicated in modulation of insulin sensitivity and lipid metabolism. Higher plasma AFABP levels are associated with increased risk of metabolic syndrome and cardiovascular morbidity in adults. Alterations in AFABP levels during fetal growth have not been characterized.
To examine AFABP levels in neonatal cord blood in relation to gestational age and birth weight.
A cross-sectional study of 361 neonates born at a tertiary academic center.
Plasma AFABP levels were measured by enzyme-linked immunosorbent assay. For comparison, venous samples from 26 adults were analyzed.
AFABP levels were higher in neonates compared with adults (P < 0.01). Preterm infants had higher AFABP levels [48.2 (31.2 to 73.3) ng/mL] compared with full-term infants [35.8 (25.1 to 51.5)] ng/mL, P < 0.01). There was a negative correlation between AFABP and gestational age (r = 0.28, P = 0.02). Among full-term infants, AFABP levels in SGA infants were lower [28.6 (24.2 to 37.3) ng/mL], compared with appropriate for gestational age [36.1 (25.5 to 50.4) ng/mL] and large for gestational age infants [45.0 (24.6 to 62.4) ng/mL, P < 0.05].
These associations may reflect the higher metabolic activity during fetal development. AFABP may also be involved in fetal growth and the association between SGA status and obesity and metabolic syndrome in later life.
小于胎龄儿（SGA）出生的婴儿肥胖和代谢综合征风险增加，但其潜在机制尚未完全阐明。脂肪细胞脂肪酸结合蛋白（AFABP）是一种脂肪因子，与胰岛素敏感性和脂质代谢的调节有关。较高的血浆AFABP水平与成人代谢综合征和心血管疾病风险增加相关。胎儿生长期间AFABP水平的变化尚未得到描述。
研究新生儿脐带血中AFABP水平与胎龄和出生体重的关系。
对一家三级学术中心出生的361名新生儿进行横断面研究。
采用酶联免疫吸附测定法测量血浆AFABP水平。为作比较，分析了26名成年人的静脉样本。
新生儿的AFABP水平高于成年人（P<0.01）。与足月儿[35.8（25.1至51.5）ng/mL]相比，早产儿的AFABP水平更高[48.2（31.2至73.3）ng/mL]，P<0.01）。AFABP与胎龄呈负相关（r = 0.28，P = 0.02）。在足月儿中，SGA婴儿的AFABP水平较低[28.6（24.2至37.3）ng/mL]，而适于胎龄儿[36.1（25.5至50.4）ng/mL]和大于胎龄儿[45.0（24.6至62.4）ng/mL]的AFABP水平较高，P<0.05]。
这些关联可能反映了胎儿发育期间较高的代谢活性。AFABP也可能参与胎儿生长以及SGA状态与晚年肥胖和代谢综合征之间的关联。
