Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany; Department of Psychiatry and Psychotherapy, Philipps University Marburg & Marburg University Hospital/UKGM, Marburg, Germany.
Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany; Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, USA.
Psychiatry Res Neuroimaging. 2017 May 30;263:44-47. doi: 10.1016/j.pscychresns.2017.02.007. Epub 2017 Feb 21.
Recent studies using surface-based morphometry of structural magnetic resonance imaging data have suggested that some changes in bipolar disorder (BP) might be neurodevelopmental in origin. We applied a novel analysis of cortical complexity based on fractal dimensions in high-resolution structural MRI scans of 18 bipolar disorder patients and 26 healthy controls. Our region-of-interest based analysis revealed increases in fractal dimensions (in patients relative to controls) in left lateral orbitofrontal cortex and right precuneus, and decreases in right caudal middle frontal, entorhinal cortex, and right pars orbitalis, and left fusiform and posterior cingulate cortices. While our analysis is preliminary, it suggests that early neurodevelopmental pathologies might contribute to bipolar disorder, possibly through genetic mechanisms.
最近的研究使用结构磁共振成像数据的表面形态计量学表明，双相障碍（BP）的一些变化可能起源于神经发育。我们在 18 名双相障碍患者和 26 名健康对照者的高分辨率结构 MRI 扫描中应用了基于分形维数的皮质复杂性的新分析。我们的基于感兴趣区域的分析显示，左侧外侧眶额皮质和右侧楔前叶的分形维数增加（相对于对照组患者），右侧尾状中额回、内嗅皮质和右侧眶额回以及左侧梭状回和后扣带回皮质的分形维数减少。虽然我们的分析是初步的，但它表明早期神经发育病理学可能通过遗传机制导致双相障碍。
