van Rhoon Gerard C, Paulides Maarten M, van Holthe Jeannette M L, Franckena Martine
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:359-362. doi: 10.1109/EMBC.2016.7590714.
Confining treatment to the tumor to improve therapeutic outcome and reduce toxicity, is a hot issue in cancer research. Hyperthermia is recognized as a strong sensitizer for radiotherapy and chemotherapy enhancing tumor control without increasing toxicity. Today's electromagnetic hyperthermia systems heat large tissue volumes with limited ability to selectively heat the tumor. Fortunately, tremendous improvements in 3-dimensional electromagnetic & temperature modelling provide an exciting opportunity to design advanced multi-element electromagnetic applicator systems. Together with feedback control using MR non-invasive thermometry and smart E-field sensors, this paves the way for selective tumor heating and potentially prescription of a thermal dose. A technological advanced hyperthermia system, with guaranteed delivery of high quality hyperthermia lowers the threshold for newcomers to apply hyperthermia. Combined with recent proof that hyperthermia blocks DNA repair and new, exciting, ways for controlled drug delivery using temperature sensitive liposome encapsulated drugs, this is expected to increase interest of the medical community in hyperthermia.
将治疗局限于肿瘤以改善治疗效果并降低毒性，是癌症研究中的一个热点问题。热疗被认为是放疗和化疗的强效增敏剂，可增强肿瘤控制而不增加毒性。当今的电磁热疗系统加热的组织体积较大，选择性加热肿瘤的能力有限。幸运的是，三维电磁和温度建模的巨大进步为设计先进的多元素电磁 applicator 系统提供了一个令人兴奋的机会。与使用磁共振无创测温法和智能电场传感器的反馈控制相结合，这为选择性肿瘤加热以及潜在的热剂量处方铺平了道路。技术先进的热疗系统，保证能提供高质量的热疗，降低了新手应用热疗的门槛。结合最近热疗可阻断 DNA 修复的证据以及使用温度敏感脂质体包裹药物进行可控药物递送的新的、令人兴奋的方法，预计这将增加医学界对热疗的兴趣。
