Njoum H, Kyriacou P A
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:611-614. doi: 10.1109/EMBC.2016.7590776.
There is a need for non-invasive and continuous blood pressure measurements. This study explored the relationship between Photoplethysmography (PPG) and Pressure-Volume (P-V) changes in an in vitro model. We proposed and compared methods for an estimation of the pulsatile volume, termed as Normalized Pulse Volume (NPV) and Adjusted Pulse Volume (APV). To validate the methods, pressure, Red (R) and InfraRed (IR) PPG signals were recorded continuously in an arterial model utilizing a pulsatile pump. Flow rates were controlled by varying pumping frequencies at low and high stroke volumes. It was found that the optimum method for estimation of the pulsatile volume is through APV, which had a high correlation (r=0.99, p<;0.001) with the assumed exponential P-V model. APV obtained a significantly better fit when compared to NPV (r=0.73, z=25.85, p<;0.001) and NPV (r=0.95, z=12.26, p<;0.001). These preliminary findings suggest that APV could be used as a potential non-invasive continuous method of blood pressure measurement.
需要进行非侵入性连续血压测量。本研究在体外模型中探讨了光电容积脉搏波描记法（PPG）与压力-容积（P-V）变化之间的关系。我们提出并比较了估计搏动容积的方法，称为归一化脉搏容积（NPV）和调整脉搏容积（APV）。为验证这些方法，利用脉动泵在动脉模型中连续记录压力、红光（R）和红外（IR）PPG信号。通过在低和高搏出量下改变泵血频率来控制流速。结果发现，估计搏动容积的最佳方法是通过APV，它与假定的指数P-V模型具有高度相关性（r=0.99，p<0.001）。与NPV（r=0.73，z=25.85，p<0.001）和NPV（r=0.95，z=12.26，p<0.001）相比，APV的拟合效果明显更好。这些初步研究结果表明，APV可作为一种潜在的非侵入性连续血压测量方法。
