Davuluri Navya S, Nimmagadda Kiran, Petrossians Artin, Humayun Mark S, Weiland James D
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:3133-3138. doi: 10.1109/EMBC.2016.7591393.
Retinitis Pigmentosa (RP) is a degenerative disease of the retina that leads to vision loss. Retinal prostheses are being developed in order to restore functional vision in patients suffering from RP. We conducted in-vivo experiments in order to identify strategies to efficiently stimulate the retina. We electrically stimulated the retina and measured electrically evoked potentials (EERs) from the superior colliculus of rats. We compared the strength of EERs when voltage-controlled and current-controlled pulses of varying pulse width and charge levels were applied to the retina. In addition to comparing EER strength, we evaluated improvement in power efficiency afforded by a high surface area platinum-iridium material. Voltage-controlled pulses were more efficient than current-controlled pulses when the pulses have a short duration (<; 1 ms) and current-controlled pulses were more efficient than voltage-controlled pulses when the pulse width was greater than 1 ms. The high surface area platinum-iridium stimulation electrode consumed power significantly lower than a standard platinum-iridium electrode.
视网膜色素变性（RP）是一种导致视力丧失的视网膜退行性疾病。目前正在研发视网膜假体，以便恢复患有视网膜色素变性的患者的功能性视力。我们进行了体内实验，以确定有效刺激视网膜的策略。我们对视网膜进行电刺激，并测量大鼠上丘的电诱发电位（EER）。当将不同脉冲宽度和电荷量的电压控制和电流控制脉冲施加到视网膜时，我们比较了EER的强度。除了比较EER强度外，我们还评估了高表面积铂铱材料所带来的功率效率的提高。当脉冲持续时间较短（<1毫秒）时，电压控制脉冲比电流控制脉冲更有效；当脉冲宽度大于1毫秒时，电流控制脉冲比电压控制脉冲更有效。高表面积铂铱刺激电极消耗的功率明显低于标准铂铱电极。
