Jamshidi Javad, Ghanbari Mehrdad, Asnaashari Ali, Jafari Nosaybeh, Valizadeh Gholam Abbas
1 Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
2 Department of Medical Genetics, Fasa University of Medical Sciences, Fasa, Iran.
Asian Cardiovasc Thorac Ann. 2017 Mar;25(3):199-203. doi: 10.1177/0218492317699752. Epub 2017 Mar 8.
Background Omentin is an adipocytokine with antiinflammatory properties. It has been reported to be involved in atherosclerosis and coronary artery disease. We aimed to investigate the association of omentin Val109Asp polymorphism with coronary artery disease in an Iranian population. Methods For a case-control study, 400 individuals were recruited: 200 with coronary artery disease and 200 healthy controls. Patients with coronary artery disease were diagnosed by angiography as having at least one main coronary artery with more than 50% stenosis. Genotyping of Val109Asp was carried out using a polymerase chain reaction DNA-restriction fragment length polymorphism technique. Results There was no association between Val109Asp polymorphism and the risk of coronary artery disease in our study population ( p = 0.20). However, when subgroup analysis was performed according to sex, there was a significant difference in the distribution of alleles between groups for men ( p = 0.031, odds ratio = 0.57, 95% confidence interval: 0.35-0.95) but not for women ( p = 0.88, odds ratio = 1.03, 95% confidence interval: 0.66-1.61). Conclusions Our results indicate that the Asp allele of Val109Asp (T allele of rs2274907) is more frequent among men with coronary artery disease than healthy men, so it is possibly a risk factor for coronary artery disease in men only. The difference in association between men and women may be due to the different distribution and metabolism of adipose tissue in men and women. More studies with larger sample sizes and in different populations are required to validate our study results.
网膜素是一种具有抗炎特性的脂肪细胞因子。据报道，它与动脉粥样硬化和冠状动脉疾病有关。我们旨在研究伊朗人群中网膜素Val109Asp多态性与冠状动脉疾病的关联。方法：在一项病例对照研究中，招募了400名个体：200名患有冠状动脉疾病的患者和200名健康对照者。冠状动脉疾病患者通过血管造影诊断为至少一条主要冠状动脉狭窄超过50%。使用聚合酶链反应DNA限制性片段长度多态性技术对Val109Asp进行基因分型。结果：在我们的研究人群中，Val109Asp多态性与冠状动脉疾病风险之间没有关联（p = 0.20）。然而，按性别进行亚组分析时，男性组间等位基因分布存在显著差异（p = 0.031，优势比 = 0.57，95%置信区间：0.35 - 0.95），而女性组间无显著差异（p = 0.88，优势比 = 1.03，95%置信区间：0.66 - 1.61）。结论：我们的结果表明，Val109Asp的Asp等位基因（rs2274907的T等位基因）在患有冠状动脉疾病的男性中比健康男性更常见，因此它可能仅是男性冠状动脉疾病的一个风险因素。男性和女性之间关联的差异可能是由于男性和女性脂肪组织的分布和代谢不同。需要更多更大样本量和不同人群的研究来验证我们的研究结果。
