Jha Chandan K, Mir Rashid, Elfaki Imadeldin, Javid Jamsheed, Babakr Abdullatif Taha, Banu Shaheena, Chahal S M S
Department of Human Genetics, Punjabi University, Punjab 147002, India.
Prince Fahd Bin Sultan Research Chair, Department of Medical Lab Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.
J Pers Med. 2020 Oct 26;10(4):194. doi: 10.3390/jpm10040194.
Coronary artery disease (CAD) is a major cause of death all over the world. CAD is caused by atherosclerosis which is induced by the interaction of genetic factors and environmental factors. Genome-wide association studies have revealed the association of certain gene polymorphisms with susceptibility to CAD. Omentin 1 is an adipokine secreted by the visceral adipose tissues and has been reported to have anti-inflammatory, cardioprotective, and enhances insulin sensitivity. In this study, we examined the role of omentin-1 common single nucleotide polymorphisms (SNPs) (rs2274907 A > T and rs2274908 G > A) in CAD. We conclude that the AT genotype and the T allele of the rs2274907 A > T is associated with Cad in the south Indian population. Our results indicated that the rs2274907 SNP may be associated with CAD in this population. This finding needs further validation in well-designed and large-sample size studies before being introduced in clinical settings.
冠状动脉疾病（CAD）是全球主要的死亡原因。CAD由动脉粥样硬化引起，而动脉粥样硬化是由遗传因素和环境因素相互作用诱发的。全基因组关联研究已经揭示了某些基因多态性与CAD易感性之间的关联。网膜素1是一种由内脏脂肪组织分泌的脂肪因子，据报道具有抗炎、心脏保护作用，并能增强胰岛素敏感性。在本研究中，我们检测了网膜素-1常见单核苷酸多态性（SNPs）（rs2274907 A>T和rs2274908 G>A）在CAD中的作用。我们得出结论，rs2274907 A>T的AT基因型和T等位基因与南印度人群的CAD相关。我们的结果表明，rs2274907 SNP可能与该人群的CAD相关。这一发现需要在设计良好且样本量较大的研究中进一步验证，才能应用于临床。
