Burrows E P, Szafraniec L L
U.S. Army Biomedical Research & Development Laboratory, Fort Detrick, Frederick, Maryland 21701-5010.
J Nat Prod. 1987 Nov-Dec;50(6):1108-12. doi: 10.1021/np50054a016.
Treatment of deoxynivalenol [3] in MeOH with hypochlorite bleach containing added NaOH gave rise to a single major product, the 9 alpha, 10 alpha, 12 beta, 13 beta-diepoxy-8,15-hemiketal 4. Thus, the reaction followed a very different course from that observed for verrucarol [2], where rearrangement involving opening of the starting 12,13-epoxide and a haloform-like oxidation took place.
在甲醇中，用添加了氢氧化钠的次氯酸盐漂白剂处理脱氧雪腐镰刀菌烯醇[3]，得到单一主要产物9α,10α,12β,13β-二环氧-8,15-半缩酮4。因此，该反应的历程与疣孢菌素[2]所观察到的非常不同，在疣孢菌素的反应中，发生了涉及起始12,13-环氧化物开环的重排和类似卤仿的氧化反应。
