Valles-Antuña C, Pérez-Haro M L, González-Ruiz de L C, Quintás-Blanco A, Tamargo-Diaz E M, García-Rodríguez J, San Martín-Blanco A, Fernandez-Gomez J M
Servicio de Neurofisiología. Hospital Universitario Central de Asturias, Oviedo.
Servicio de Urología. Hospital Universitario Central de Asturias, Oviedo.
Actas Urol Esp. 2017 Sep;41(7):465-470. doi: 10.1016/j.acuro.2017.01.009. Epub 2017 Mar 18.
To assess the efficacy of treatment with transcutaneous posterior tibial nerve stimulation (TPTNS) in patients with urge urinary incontinence, of neurogenic or nonneurogenic origin, refractory to first-line therapeutic options.
We included 65 patients with urge urinary incontinence refractory to medical treatment. A case history review, a urodynamic study and a somatosensory evoked potentials (SEP) study were conducted before the TPTNS, studying the functional urological condition by means of a voiding diary. The treatment consisted of 10 weekly sessions of TPTNS lasting 30minutes.
Some 57.7% of the patients showed abnormal tibial SEPs, and 42% showed abnormal pudendal SEPs. A statistically significant symptomatic improvement was observed in all clinical parameters after treatment with TPTNS, and 66% of the patients showed an overall improvement, regardless of sex, the presence of underlying neurological disorders, detrusor hyperactivity in the urodynamic study or SEP disorders. There were no adverse effects during the treatment.
TPTNS is an effective and well tolerated treatment in patients with urge incontinence refractory to first-line therapies and should be offered early in the treatment strategy. New studies are needed to identify the optimal parameters of stimulation, the most effective treatment protocols and long-term efficacy, as well as its applicability to patients with a neurogenic substrate.
评估经皮胫后神经刺激(TPTNS)疗法对一线治疗方案难治的神经源性或非神经源性急迫性尿失禁患者的疗效。
我们纳入了65例药物治疗难治的急迫性尿失禁患者。在进行TPTNS治疗前,进行了病史回顾、尿动力学研究和体感诱发电位(SEP)研究,并通过排尿日记研究泌尿功能状况。治疗包括每周进行10次,每次持续30分钟的TPTNS治疗。
约57.7%的患者胫神经SEP异常,42%的患者阴部神经SEP异常。TPTNS治疗后,所有临床参数均出现了具有统计学意义的症状改善,66%的患者总体病情得到改善,无论性别、是否存在潜在神经系统疾病、尿动力学研究中的逼尿肌过度活动或SEP异常。治疗期间未出现不良反应。
TPTNS是一种对一线治疗难治的急迫性尿失禁患者有效且耐受性良好的治疗方法,应在治疗策略中尽早采用。需要开展新的研究,以确定最佳刺激参数、最有效的治疗方案和长期疗效,以及其对神经源性患者的适用性。