O'Connor John P, Hanley Brian M, Mulcahey Thomas I, Sheets Ellen E, Shuey Kacey W
CSA Medical, Inc. 91 Hartwell Avenue, Lexington MA 02421, USA.
CSA Medical, Inc. 91 Hartwell Avenue, Lexington MA 02421, USA.
Med Eng Phys. 2017 Jun;44:63-72. doi: 10.1016/j.medengphy.2017.02.017. Epub 2017 Mar 18.
Spray cryotherapy using liquid nitrogen (LN) is a general surgical tool used to ablate benign or malignant lesions. Adequate egress of the gaseous nitrogen (N) generated during this process must be provided for safe use when LN is used within the body rather than topically. When delivered to either the gastrointestinal tract (requiring active venting via a suction tube) or body cavities open to room barometric pressure (such as lung airways) allowing for passive venting, the N gas generated from the boiling process must be evacuated. This work will examine the egress of N during procedures requiring passive venting from human airways undergoing liquid nitrogen spray cryotherapy. Venting characteristics for safe N egress will be presented and discussed based on analytical modeling using fluid mechanics simulations and experimental studies of N venting with laboratory and porcine models.
使用液氮（LN）的喷雾冷冻疗法是一种用于切除良性或恶性病变的普通外科工具。当在体内而非局部使用液氮时，必须确保在此过程中产生的气态氮（N）有足够的排出途径，以确保安全使用。当应用于胃肠道（需要通过吸管进行主动排气）或向大气开放的体腔（如肺气道，可进行被动排气）时，沸腾过程中产生的氮气必须排出。这项工作将研究在对接受液氮喷雾冷冻疗法的人体气道进行被动排气的手术过程中氮气的排出情况。将基于流体力学模拟的分析模型以及使用实验室模型和猪模型进行的氮气排放实验研究，展示并讨论安全排出氮气的排气特性。
