Park Young-Min
Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.
Psychiatry Investig. 2017 Mar;14(2):136-140. doi: 10.4306/pi.2017.14.2.136. Epub 2017 Mar 6.
The aims of current study were to determine whether childhood maltreatment contributes to the occurrence of major depressive disorder (MDD) with bipolarity or suicidality.
In total, 132 outpatients diagnosed with MDD between 2014 and 2015 on the medical records were included. The subjects were divided into two groups according to the presence of childhood maltreatment (CM group) and no childhood maltreatment (NCM group). Depression severity and bipolarity were identified using Beck Depression Inventory (BDI) and the Korean version of Mood Disorder Questionnaire (K-MDQ) respectively on the medical records. In addition, the baseline loud dependence of auditory evoked potentials of 36 patients on medical records were analyzed.
The mean total BDI, BDI item 9 (suicide ideation), and total K-MDQ score were significantly higher in the CM group than the NCM group. The number of subjects with bipolarity was significantly higher in the CM than in the NCM group. Furthermore two thirds subjects experienced the significant maltreatment during childhood. The central serotonergic activity of the CM group was also lower than that of the NCM group.
The findings of this study support that there is a relationship between childhood maltreatment and bipolarity or suicidality in patients with MDD.
本研究旨在确定童年期受虐是否会导致伴有双相情感障碍或自杀倾向的重度抑郁症（MDD）的发生。
总共纳入了132名在2014年至2015年期间病历诊断为MDD的门诊患者。根据是否有童年期受虐情况，将受试者分为两组（童年期受虐组[CM组]和无童年期受虐组[NCM组]）。分别根据病历使用贝克抑郁量表（BDI）和韩语版心境障碍问卷（K-MDQ）确定抑郁严重程度和双相情感障碍情况。此外，分析了36例患者病历中听觉诱发电位的基线响度依赖性。
CM组的BDI总分、BDI第9项（自杀观念）以及K-MDQ总分均显著高于NCM组。CM组中双相情感障碍患者的数量显著高于NCM组。此外，三分之二的受试者在童年期经历过严重虐待。CM组的中枢5-羟色胺能活性也低于NCM组。
本研究结果支持童年期受虐与MDD患者的双相情感障碍或自杀倾向之间存在关联。
