Lee Yong-Seong, Kim Sang-Dae, Kang Hee-Ju, Kim Sung-Wan, Shin Il-Seon, Yoon Jin-Sang, Kim Jae-Min
Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea.
Psychiatry Investig. 2017 Mar;14(2):150-157. doi: 10.4306/pi.2017.14.2.150. Epub 2017 Mar 6.
Previous studies have reported an association between weight loss and cognitive impairment. Changes in anthropometric measurements, such as arm and thigh circumferences, are associated with body mass changes and physical activity. Our aim was to investigate the association of upper arm and thigh circumferences with dementia and depression in the community-dwelling elderly population.
In total, 2,498 community residents aged 65 years or over were clinically assessed for dementia using the Korean version of the Community Screening Interview for Dementia. Depression was also assessed using the Korean version of the Geriatric Mental State Schedule B3. Arm and thigh circumferences were measured. Complex sample logistic regression was performed to evaluate associations of changes in anthropometric measurements with dementia/depression after controlling for other covariates.
In the adjusted analyses, there was an independent association between dementia and arm circumference (OR=1.12; 95% CI=1.06-1.19). This association was significant in the females (OR=1.12; 95% CI=1.05-1.19) but not in males (OR=1.07; 95% CI=0.93-1.28). The association between dementia and thigh circumference was not significant in the adjusted analysis (OR=1.03; 95% CI=0.99-1.07). No significant association was found between either upper arm or thigh circumference and depression.
In the older female Korean population, decreased upper arm circumference was associated with dementia and may represent a biological marker for this condition. This association may be explained by nutritional deficits or decreased physical activity.
以往研究报告了体重减轻与认知障碍之间的关联。人体测量指标的变化，如上臂和大腿围，与体重变化和身体活动有关。我们的目的是调查社区居住老年人群中上臂和大腿围与痴呆症和抑郁症之间的关联。
总共对2498名65岁及以上的社区居民使用韩国版痴呆症社区筛查访谈进行痴呆症临床评估。还使用韩国版老年精神状态检查表B3评估抑郁症。测量上臂和大腿围。在控制其他协变量后，进行复杂样本逻辑回归以评估人体测量指标变化与痴呆症/抑郁症之间的关联。
在调整分析中，痴呆症与上臂围之间存在独立关联（OR = 1.12；95% CI = 1.06 - 1.19）。这种关联在女性中显著（OR = 1.12；95% CI = 1.05 - 1.19），但在男性中不显著（OR = 1.07；95% CI = 0.93 - 1.28）。在调整分析中，痴呆症与大腿围之间的关联不显著（OR = 1.03；95% CI = 0.99 - 1.07）。未发现上臂围或大腿围与抑郁症之间存在显著关联。
在韩国老年女性人群中，上臂围减小与痴呆症有关，可能代表该疾病的一个生物学标志物。这种关联可能由营养缺乏或身体活动减少来解释。
