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长期给予茶渍酸A对肾质量减少大鼠模型肾功能和氧化应激的影响

The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction.

作者信息

Nogueira António, Peixoto Francisco, Oliveira Maria Manuel, Pires Carlos André, Colaço Bruno, Oliveira Paula Alexandra, Pires Maria João

机构信息

Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal; Department of Therapeutic and Diagnostic Technologies, Polytechnic Institute of Bragança (IPB), Bragança, Portugal.

Department of Biology and Environment, School of Life Science and Environment, UTAD, Vila Real, Portugal; Center for the Research and Technology of Agro-Environmental and Biological Science (CITAB), UTAD, Vila Real, Portugal.

出版信息

Biomed Res Int. 2017;2017:5125980. doi: 10.1155/2017/5125980. Epub 2017 Feb 23.

DOI:10.1155/2017/5125980
PMID:28326323
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5343227/
Abstract

This study aimed to evaluate the effect of chronic treatment with chaetomellic acid A (CAA) on oxidative stress and renal function in a model of renal mass reduction. . Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been divided into four experimental groups: RMR: RMR rats without treatment ( = 14); RMR + CAA: RMR rats treated with CAA ( = 13); SO: SO rats without treatment ( = 13); and SO + CAA: SO rats treated with CAA ( = 13). CAA was intraperitoneally administered in a dose of 0.23 g/Kg three times a week for six months. RMR was accompanied by a significant reduction in catalase and glutathione reductase (GR) activity ( < 0.05) and a decrease in reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio. CAA administration significantly increased catalase and GR activity ( < 0.05) and increased GSH/GSSG ratio, but no significant difference between the treated and nontreated groups was found in this ratio. No significant differences were found between the RMR groups in any of the parameters of renal function. However, CAA administration slightly improves some parameters of renal function. These data suggest that CAA could attenuate 5/6 RMR-induced oxidative stress.

摘要

本研究旨在评估在肾质量减少模型中，长期用茶渍酸A（CAA）治疗对氧化应激和肾功能的影响。雄性Wistar大鼠接受5/6肾切除术（RMR）或假手术（SO）。术后一周，大鼠被分为四个实验组：RMR组：未治疗的RMR大鼠（n = 14）；RMR + CAA组：用CAA治疗的RMR大鼠（n = 13）；SO组：未治疗的SO大鼠（n = 13）；SO + CAA组：用CAA治疗的SO大鼠（n = 13）。CAA以0.23 g/Kg的剂量每周腹腔注射三次，持续六个月。RMR伴随着过氧化氢酶和谷胱甘肽还原酶（GR）活性的显著降低（P < 0.05）以及还原型谷胱甘肽（GSH）/氧化型谷胱甘肽（GSSG）比值的下降。给予CAA显著增加了过氧化氢酶和GR活性（P < 0.05）并提高了GSH/GSSG比值，但在该比值上，治疗组与未治疗组之间未发现显著差异。在肾功能的任何参数方面，RMR组之间均未发现显著差异。然而，给予CAA略微改善了一些肾功能参数。这些数据表明，CAA可以减轻5/6 RMR诱导的氧化应激。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7836/5343227/507d8f50b6b6/BMRI2017-5125980.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7836/5343227/c0791ca965f8/BMRI2017-5125980.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7836/5343227/507d8f50b6b6/BMRI2017-5125980.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7836/5343227/c0791ca965f8/BMRI2017-5125980.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7836/5343227/507d8f50b6b6/BMRI2017-5125980.002.jpg

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