非人灵长类动物模型在帕金森病细胞治疗药物开发中的作用。

Neuroscience Training Program, University of Wisconsin, Madison, 1220 Capitol Court, Madison, WI, 53715, USA.

Wisconsin National Primate Research Center, University of Wisconsin, Madison, USA.

J Neural Transm (Vienna). 2018 Mar;125(3):365-384. doi: 10.1007/s00702-017-1708-9. Epub 2017 Mar 22.

Through the course of over three decades, nonhuman primate (NHP) studies on cell-based therapies (CBTs) for Parkinson's disease (PD) have provided insight into the feasibility, safety and efficacy of the approach, methods of cell collection and preparation, cell viability, as well as potential brain targets. Today, NHP research continues to be a vital source of information for improving cell grafts and analyzing how the host affects graft survival, integration and function. Overall, this article aims to discuss the role that NHP models of PD have played in CBT development and highlights specific issues that need to be considered to maximize the value of NHP studies for the successful clinical translation of CBTs.

在过去的三十多年里，非人类灵长类动物（NHP）在细胞疗法（CBT）治疗帕金森病（PD）方面的研究为该方法的可行性、安全性和有效性提供了深入的了解，包括细胞采集和制备方法、细胞活力以及潜在的大脑靶点。如今，NHP 研究仍然是改善细胞移植和分析宿主如何影响移植物存活、整合和功能的重要信息来源。总的来说，本文旨在讨论 PD 的 NHP 模型在 CBT 发展中所扮演的角色，并强调需要考虑哪些具体问题，以最大限度地提高 NHP 研究在成功将 CBT 临床转化方面的价值。