Diniz Gulden, Karadeniz Tugba, Sayhan Sevil, Akata Talya, Aydiner Fatma, Ayaz Duygu, Solakoglu Kahraman Dudu, Akman Tulay
Tepecik Training and Research Hospital, Department of Pathology, Izmir, Turkey.
Ginekol Pol. 2017;88(2):51-55. doi: 10.5603/GP.a2017.0011.
Human Epididymal Secretory Protein 4 was firstly described as an epididymis-specific protein but more recently it has been demonstrated to be a putative serum tumor marker for different malignancies, especially ovarian epithelial cancers. The aim of this study is to investigate the association between tissue Human Epididymal Secretory Protein 4 expression and the clinicopathological features of uterine cervical tumors.
This retrospective study was designed to evaluate the differences of tissue expressions of Human Epididymal Secretory Protein 4 protein in a spectrum of cervical neoplasms. One hundred and seven patients recently diagnosed as having cervical intraepithelial neoplasm or invasive squamous cell carcinoma, adenosquamous carcinoma and adenocarcinoma based on pathology databases.
Decreased or negative Human Epididymal Secretory Protein 4 expressions were determined in both normal cervical epithelia and in intraepithelial carcinomas, while increased HE4 expression was observed in invasive tumors.
This study demonstrated that altered expression of Human Epididymal Secretory Protein 4 may involve in tumorigenesis in the uterine cervix. Our findings also suggested the presence of a correlation between Human Epididymal Secretory Protein 4 expression and the invasive potential of uterine tumors. Therefore it may be thought that the tissue expression of HE4 can be used to differentiate high grade intraepithelial tumors from carcinomas.
人附睾分泌蛋白4最初被描述为附睾特异性蛋白，但最近已被证明是不同恶性肿瘤，尤其是卵巢上皮癌的一种假定血清肿瘤标志物。本研究的目的是探讨组织中人附睾分泌蛋白4的表达与子宫颈肿瘤临床病理特征之间的关联。
本回顾性研究旨在评估一系列宫颈肿瘤中人附睾分泌蛋白4蛋白组织表达的差异。根据病理数据库，选取了107例近期被诊断为宫颈上皮内瘤变或浸润性鳞状细胞癌、腺鳞癌和腺癌的患者。
在正常宫颈上皮和上皮内癌中均检测到人附睾分泌蛋白4表达降低或呈阴性，而在浸润性肿瘤中观察到HE4表达增加。
本研究表明，人附睾分泌蛋白4表达的改变可能参与子宫颈肿瘤的发生。我们的研究结果还提示人附睾分泌蛋白4表达与子宫肿瘤的浸润潜能之间存在相关性。因此，可以认为HE4的组织表达可用于区分高级别上皮内肿瘤和癌。
