整合素α2β1与药物性牙龈增生关系的研究进展
[Research progression of the relationship between integrin α2β1 and drug-induced gingival overgrowth].
作者信息
Yingzhu Kang, Shujuan Guo, Chengcheng Liu, Yi Ding
机构信息
State Key Laboratory of Oral Diseases, Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
出版信息
Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Feb 1;35(1):99-103. doi: 10.7518/hxkq.2017.01.016.
Abstract
Drug-induced gingival overgrowth (DIGO) is characterized by fibrous gingival hyperplasia and increased gingival volume. DIGO is histologically associated with proliferation of cells and deposition of extracellular matrices, particularly collagen. Integrin α2β1 is related to collagen phagocytosis and involved in the occurrence and progression of DIGO. This paper reviews the progress of research on the relationship between integrin α2β1 and DIGO.
摘要
药物性牙龈增生（DIGO）的特征是牙龈纤维性增生和牙龈体积增大。DIGO在组织学上与细胞增殖和细胞外基质尤其是胶原蛋白的沉积有关。整合素α2β1与胶原蛋白吞噬有关，并参与DIGO的发生和发展。本文综述了整合素α2β1与DIGO关系的研究进展。
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