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整合素α2β1与药物性牙龈增生关系的研究进展

[Research progression of the relationship between integrin α2β1 and drug-induced gingival overgrowth].

作者信息

Yingzhu Kang, Shujuan Guo, Chengcheng Liu, Yi Ding

机构信息

State Key Laboratory of Oral Diseases, Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

出版信息

Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Feb 1;35(1):99-103. doi: 10.7518/hxkq.2017.01.016.

DOI:10.7518/hxkq.2017.01.016
PMID:28326736
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7030208/
Abstract

Drug-induced gingival overgrowth (DIGO) is characterized by fibrous gingival hyperplasia and increased gingival volume. DIGO is histologically associated with proliferation of cells and deposition of extracellular matrices, particularly collagen. Integrin α2β1 is related to collagen phagocytosis and involved in the occurrence and progression of DIGO. This paper reviews the progress of research on the relationship between integrin α2β1 and DIGO.

摘要

药物性牙龈增生（DIGO）的特征是牙龈纤维性增生和牙龈体积增大。DIGO在组织学上与细胞增殖和细胞外基质尤其是胶原蛋白的沉积有关。整合素α2β1与胶原蛋白吞噬有关，并参与DIGO的发生和发展。本文综述了整合素α2β1与DIGO关系的研究进展。

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1
[Research progression of the relationship between integrin α2β1 and drug-induced gingival overgrowth].整合素α2β1与药物性牙龈增生关系的研究进展
Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Feb 1;35(1):99-103. doi: 10.7518/hxkq.2017.01.016.
2
Decreased expression of alpha2 integrin in fibroblasts isolated from cyclosporin A- induced gingival overgrowth in rats.从环孢素A诱导的大鼠牙龈过度生长中分离出的成纤维细胞中α2整合素表达降低。
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Nifedipine induces gingival overgrowth in rats through a reduction in collagen phagocytosis by gingival fibroblasts.硝苯地平通过减少牙龈成纤维细胞对胶原蛋白的吞噬作用，诱导大鼠牙龈增生。
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本文引用的文献

1
Endocytic Trafficking of Integrins in Cell Migration.整合素在内质网转运在细胞迁移中的作用。
Curr Biol. 2015 Nov 16;25(22):R1092-105. doi: 10.1016/j.cub.2015.09.049.
2
Signaling in Fibrosis: TGF-β, WNT, and YAP/TAZ Converge.纤维化信号通路：TGF-β、WNT 和 YAP/TAZ 汇聚。
Front Med (Lausanne). 2015 Sep 3;2:59. doi: 10.3389/fmed.2015.00059. eCollection 2015.
3
Gingival enlargements: Differential diagnosis and review of literature.牙龈增生：鉴别诊断与文献综述
World J Clin Cases. 2015 Sep 16;3(9):779-88. doi: 10.12998/wjcc.v3.i9.779.
4
Role of discoidin domain receptor 1 in dysregulation of collagen remodeling by cyclosporin A.盘状结构域受体1在环孢素A导致的胶原重塑失调中的作用
Int J Biochem Cell Biol. 2015 May;62:80-7. doi: 10.1016/j.biocel.2015.02.019. Epub 2015 Mar 6.
5
Local Inflammation Alters MMP-2 and MMP-9 Gelatinase Expression Associated with the Severity of Nifedipine-Induced Gingival Overgrowth: a Rat Model Study.局部炎症改变与硝苯地平诱导的牙龈过度生长严重程度相关的MMP-2和MMP-9明胶酶表达：一项大鼠模型研究。
Inflammation. 2015 Aug;38(4):1517-28. doi: 10.1007/s10753-015-0126-0.
6
Altered oxidative status and integrin expression in cyclosporine A-treated oral epithelial cells.环孢素A处理的口腔上皮细胞中氧化状态和整合素表达的改变
Toxicol Mech Methods. 2015 Feb;25(2):98-104. doi: 10.3109/15376516.2014.990595. Epub 2015 Jan 22.
7
Role of Shh and TGF in cyclosporine-enhanced expression of collagen and α-SMA by gingival fibroblast.Shh 和 TGF 在环孢素增强牙龈成纤维细胞胶原和α-SMA 表达中的作用。
J Clin Periodontol. 2015 Jan;42(1):29-36. doi: 10.1111/jcpe.12333. Epub 2015 Jan 9.
8
Cellular signaling by collagen-binding integrins.整合素通过胶原蛋白进行细胞信号传递。
Adv Exp Med Biol. 2014;819:143-55. doi: 10.1007/978-94-017-9153-3_10.
9
α2β1 Integrin.α2β1 整合素。
Adv Exp Med Biol. 2014;819:41-60. doi: 10.1007/978-94-017-9153-3_3.
10
Role of transforming growth factor β-connective tissue growth factor pathway in dihydropyridine calcium channel blockers-induced gingival overgrowth.转化生长因子β-结缔组织生长因子通路在二氢吡啶类钙通道阻滞剂所致牙龈增生中的作用
Rom J Morphol Embryol. 2014;55(2):285-90.