从烟草根中分离出的三种新异苯并呋喃及其生物活性。
Three new isobenzofurans from the roots of Nicotiana Tabacum and their bioactivities.
作者信息
He Pei, Yang Peisong, Tang Shiyun, Ye Ling, Liu Chunbo, Shen Qinpeng, Tang Dangyu, Zhang Fengmei, Liu Zhihua, Chen Yongkuan, Yao Shouzhuo, Xiang Nengjun, Huang Zhangjie
机构信息
a Key Laboratory of Tobacco Chemistry of Yunnan Province , China tobacco yunnan industrial Co., Ltd , Kunming , P.R. China.
b School of Chemical Science and Technology , Yunnan University , Kunming , P.R. China.
出版信息
Nat Prod Res. 2017 Dec;31(23):2730-2736. doi: 10.1080/14786419.2017.1292512. Epub 2017 Mar 22.
Three new isobenzofurans (1-3), together with four known phenylpropanoids (4-7) were isolated from the roots of Nicotiana tabacum. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-6 were tested for their anti-tobacco mosaic virus (anti-TMV) activities and cytotoxicity activities. The results showed that compounds 5 and 6 exhibited high anti-TMV activities with inhibition rates of 35.1 and 33.4%, respectively. The cytotoxicities of compounds 1-7 against five human tumor cell lines (NB4, A549, SHSY5Y, PC3 were also tested. Compounds 1-7 showed weak inhibitory activities against some tested human tumor cell lines with IC values in the range of 3.8-9.6 μM.
从烟草的根部分离出三种新的异苯并呋喃（1-3）以及四种已知的苯丙素类化合物（4-7）。通过高分辨电喷雾电离质谱（HRESIMS）以及广泛的一维和二维核磁共振光谱研究确定了它们的结构。测试了化合物1-6的抗烟草花叶病毒（抗TMV）活性和细胞毒性活性。结果表明，化合物5和6表现出较高的抗TMV活性，抑制率分别为35.1%和33.4%。还测试了化合物1-7对五种人类肿瘤细胞系（NB4、A549、SHSY5Y、PC3）的细胞毒性。化合物1-7对一些测试的人类肿瘤细胞系显示出较弱的抑制活性，IC值在3.8-9.6μM范围内。
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