薰衣草中的三种新苯丙素类化合物及其生物活性。
Three new phenylpropanoids from Lavandula angustifolia and their bioactivities.
作者信息
Tang Shiyun, Shi Jianlian, Liu Chunbo, Jiang Rui, Zhao Wei, Liu Xin, Xiang Nengjun, Chen Yongkuan, Shen Qinpeng, Miao Mingming, Liu Zhihua, Yang Guangyu
机构信息
a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
b Yunnan Key Laboratory of Pharmacology for Nature Products , School of Pharmaceutical Science , Kunming , P.R. China.
出版信息
Nat Prod Res. 2017 Jun;31(12):1351-1357. doi: 10.1080/14786419.2016.1247081. Epub 2016 Oct 21.
Three new phenylpropanoids, 3-(3,4-dimethoxy-5-methylphenyl)-3-oxopropyl acetate (1), 3-hydroxy-1-(3,4-dimethoxy-5-methylphenyl)propan-1-one (2), and 3-hydroxy-1-(4-methylbenzo[d][1,3]dioxol-6-yl) propan-1-one (3), together with three known phenylpropanoids (4-6) were isolated from the whole plant of Lavandula angustifolia. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-6 were tested for their anti-tobacoo mosaic virus (TMV) activities and cytotoxicity activities. The results revealed that compounds 1-3 showed high anti-TMV activity with inhibition rate of 35.2, 38.4 and 33.9%. These rates are higher than that of positive control. The other compounds also showed potential anti-TMV activities with inhibition rates in the range of 26.8-28.9%, respectively. Compounds 1-6 also showed weak inhibitory activities against some tested human tumour cell lines with IC50 values in the range of 3.8-8.8 μM.
从狭叶薰衣草全株中分离出三种新的苯丙素类化合物，3-(3,4-二甲氧基-5-甲基苯基)-3-氧代丙基乙酸酯(1)、3-羟基-1-(3,4-二甲氧基-5-甲基苯基)丙-1-酮(2)和3-羟基-1-(4-甲基苯并[d][1,3]二氧杂环戊烯-6-基)丙-1-酮(3)，以及三种已知的苯丙素类化合物(4-6)。通过高分辨电喷雾电离质谱(HRESIMS)以及广泛的一维和二维核磁共振光谱研究确定了它们的结构。对化合物1-6进行了抗烟草花叶病毒(TMV)活性和细胞毒性活性测试。结果表明，化合物1-3表现出较高的抗TMV活性，抑制率分别为35.2%、38.4%和33.9%。这些抑制率高于阳性对照。其他化合物也表现出潜在的抗TMV活性，抑制率分别在26.8%-28.9%范围内。化合物1-6对一些测试的人类肿瘤细胞系也表现出较弱的抑制活性，IC50值在3.8-8.8 μM范围内。
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