Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, China.
Center for Disease Prevention and Control of Gusu District, Suzhou, China.
Clin Chim Acta. 2017 Jun;469:26-30. doi: 10.1016/j.cca.2017.03.019. Epub 2017 Mar 19.
Atrial natriuretic peptide (ANP) and its prohormone activating enzyme are associated with central obesity, suggesting there may be a potential relationship between proANP and central obesity. However, the association is still lack of population-based evidence. We explored the association in a general population of China.
We measured plasma proANP, waist circumference and other traditional biomarkers in 2203 participants aged≥30y. Multivariate logistic regression models were used to determine the association between plasma proANP and central obesity, and odds ratio (OR) and 95% confidence interval (CI) were calculated.
High proANP was significantly associated with increased risk of central obesity in participants, and the multivariate adjusted OR (95% CI) of central obesity associated with the second, third and fourth quartiles of proANP were 1.33 (1.03-1.72), 1.69 (1.31-2.19) and 1.76 (1.35-2.29), respectively, compared with the lowest quartile of proANP. There was a dose-response relationship between proANP and risk of central obesity among the participants (P<0.001). Sensitivity analyses further confirmed these associations. Adding proANP to a model containing conventional risk factors improved discriminatory power of central obesity (as shown by significant improvement in continuous NRI and IDI).
Contrary to known reduced ANP levels in central obesity, we found that plasma proANP was positively associated with central obesity, suggesting that elevated plasma proANP may be a marker or a risk factor for central obesity.
心钠肽（ANP）及其前体激活酶与中心性肥胖有关，提示前体 ANP 与中心性肥胖之间可能存在潜在关系。然而，这种相关性在人群中仍缺乏证据。我们在中国的一般人群中对此进行了研究。
我们在 2203 名年龄≥30 岁的参与者中测量了血浆前体 ANP、腰围和其他传统生物标志物。采用多变量逻辑回归模型来确定血浆前体 ANP 与中心性肥胖之间的关联，并计算比值比（OR）和 95%置信区间（CI）。
高前体 ANP 与参与者中心性肥胖的风险增加显著相关，与前体 ANP 第二、三、四分位的中心性肥胖相关的多变量调整 OR（95%CI）分别为 1.33（1.03-1.72）、1.69（1.31-2.19）和 1.76（1.35-2.29），与前体 ANP 的最低四分位相比。在前体 ANP 与中心性肥胖风险之间存在剂量-反应关系（P<0.001）。敏感性分析进一步证实了这些关联。在前体 ANP 中加入包含传统危险因素的模型中，可以改善中心性肥胖的区分能力（表现为连续 NRI 和 IDI 的显著改善）。
与已知的中心性肥胖中 ANP 水平降低相反，我们发现血浆前体 ANP 与中心性肥胖呈正相关，提示升高的血浆前体 ANP 可能是中心性肥胖的标志物或危险因素。
