Leone Beniamino, Di Nicola Marco, Moccia Lorenzo, Pettorruso Mauro, De Risio Luisa, Nucara Giuseppe, Zamboni Lorenzo, Callea Antonino, Janiri Luigi, Cibin Mauro, Lugoboni Fabio
Institute of Psychiatry and Psychology, Fondazione Policlinico Universitario "A. Gemelli", Catholic University of Sacred Heart, Rome, Italy.
Institute of Psychiatry and Psychology, Fondazione Policlinico Universitario "A. Gemelli", Catholic University of Sacred Heart, Rome, Italy.
Addict Behav. 2017 Aug;71:107-110. doi: 10.1016/j.addbeh.2017.03.010. Epub 2017 Mar 10.
Gender and psychiatric comorbidity seem to influence patients' inter-individual response to Opioid Substitution Treatments (OST) in Opioid Use Disorder (OUD) management. The aim of the study was to assess psychopathological dimensions in an Italian sample of OUD individuals entering a methadone/buprenorphine maintenance program; secondary, we evaluated the possible gender-specific differences within the psychopathological profiles.
In a cross-sectional study, we recruited 1052 (792 male; 260 female) OUD subjects receiving OST. All patients underwent a clinical and psychometric evaluation assessing demographics, psychiatric history, psychopathological features via the Symptom Checklist-90-Revised (SCL-90-R), and were prescribed psychopharmacological treatments.
Our results reveal gender-specific differences in a real-world sample of opioid-maintained OUD individuals attending public addiction services in Italy. Compared to men, women reported higher scores in both General Symptomatic Index (GSI) and in all the SCL-90-R sub-scales. No impact of pharmacological treatment was detected. Finally, regression analysis revealed that being in methadone-maintenance group was significantly associated with high GSI scores in the male, but not female, group.
Increasing the knowledge of psychopathological dimensions in patients with OST, with relevance to gender differences, is important for a better understanding of factors that influence the outcome and for further development in gender-tailored strategies.
在阿片类物质使用障碍（OUD）管理中，性别和精神疾病共病似乎会影响患者对阿片类物质替代治疗（OST）的个体间反应。本研究的目的是评估进入美沙酮/丁丙诺啡维持治疗项目的意大利OUD个体样本中的精神病理学维度；其次，我们评估了精神病理学特征中可能存在的性别差异。
在一项横断面研究中，我们招募了1052名接受OST的OUD受试者（792名男性；260名女性）。所有患者均接受了临床和心理测量评估，通过症状自评量表90修订版（SCL-90-R）评估人口统计学、精神病史、精神病理学特征，并接受了精神药物治疗。
我们的研究结果揭示了在意大利接受公共成瘾服务的阿片类物质维持治疗的OUD个体的真实样本中存在性别差异。与男性相比，女性在总体症状指数（GSI）和所有SCL-90-R子量表中的得分更高。未检测到药物治疗的影响。最后，回归分析显示，美沙酮维持治疗组与男性而非女性的高GSI得分显著相关。
增加对接受OST治疗患者精神病理学维度的了解，尤其是与性别差异相关的内容，对于更好地理解影响治疗结果的因素以及进一步制定针对性别的策略非常重要。
