Mayo R Alex, Sullivan David J, Fillion Travis A P, Kycia Stefan W, Soldatov Dmitriy V, Preuss Kathryn E
Department of Chemistry, University of Guelph, Guelph, ON N1G 2W1, Canada.
Department of Physics, University of Guelph, Guelph, ON N1G 2W1, Canada.
Chem Commun (Camb). 2017 Apr 4;53(28):3964-3966. doi: 10.1039/c7cc00907k.
An achiral organic molecule adopts a chiral conformation, crystallizing in two morphologies: a racemic form, stable <70 °C, and a homochiral form, stable ≥70 °C. Upon seeding, crystal-to-crystal phase transitions occur reversibly between the racemic and chiral forms. Liquid-to-solid chiral crystallization is observed >90% of the time from the melt.
一种非手性有机分子呈现出手性构象，以两种形态结晶：一种外消旋形式，在低于70°C时稳定；另一种纯手性形式，在70°C及以上时稳定。在晶种作用下，外消旋和手性形式之间会可逆地发生晶型到晶型的相变。从熔体中进行液-固手性结晶的情况在90%以上的时间里都能观察到。
