Joffe R T, Post R M, Sulser F, Weiss S R
Biological Psychiatry Branch, NIMH, Bethesda, Maryland.
Neuropharmacology. 1988 Feb;27(2):171-4. doi: 10.1016/0028-3908(88)90167-0.
The effect of alteration in thyroid status on beta adrenergic receptors in the cortex of the rat was assessed. Normal animals were treated with large doses of thyroxine (T4) and triiodothyronine (T3) and thyroidectomized animals were treated with physiological replacement doses of T4 and T3 in order to assess the possible differential effects of these hormones. In addition, a group of rats was treated with a diet of carbamazepine (an anticonvulsant also used in the treatment of manic-depressive illness), which has been shown to reduce peripheral levels of thyroid hormone in humans. The intended manipulations of the thyroid were achieved by the various treatments with thyroid hormone, and carbamazepine-diet-treated animals had significantly lower plasma T4 levels as compared with controls. No significant alteration in the density or affinity of beta-adrenergic receptors in the cortex was noted with major, short-term alterations in thyroid status or with treatment with carbamazepine. It is concluded that even marked, but relatively short-term, changes in thyroid status do not necessarily affect beta-receptors in the cerebral cortex and that carbamazepine may represent an exception to the general proposition that antidepressant agents decrease the number of beta-receptors.
评估了甲状腺状态改变对大鼠皮质中β-肾上腺素能受体的影响。为了评估这些激素可能存在的差异效应，对正常动物给予大剂量甲状腺素（T4）和三碘甲状腺原氨酸（T3），对甲状腺切除的动物给予生理替代剂量的T4和T3。此外，给一组大鼠喂食卡马西平（一种也用于治疗躁狂抑郁症的抗惊厥药），已表明该药物可降低人体外周甲状腺激素水平。通过各种甲状腺激素治疗实现了对甲状腺的预期操作，与对照组相比，卡马西平饮食治疗的动物血浆T4水平显著降低。甲状腺状态的主要短期改变或卡马西平治疗并未使皮质中β-肾上腺素能受体的密度或亲和力发生显著改变。得出的结论是，即使甲状腺状态发生明显但相对短期的变化，也不一定会影响大脑皮质中的β受体，并且卡马西平可能是抗抑郁药会减少β受体数量这一普遍观点的一个例外。
