Balaguer Mònica, Alejandre Carme, Vila David, Esteban Elisabeth, Carrasco Josep L, Cambra Francisco José, Jordan Iolanda
Pediatric Critical Care Unit, Hospital Sant Joan de Deu, Pg. Sant Joan de Deu n°2, Esplugues de Llobregat 08950, Barcelona, Spain.
Biostatistics, Public Health Department, University of Barcelona, Barcelona, Spain.
Pediatr Pulmonol. 2017 Apr;52(4):533-539. doi: 10.1002/ppul.23546. Epub 2016 Nov 7.
To validate the bronchiolitis score of Sant Joan de Déu (BROSJOD) and to examine the previously defined scoring cutoff.
Prospective, observational study. BROSJOD scoring was done by two independent physicians (at admission, 24 and 48 hr). Internal consistency of the score was assessed using Cronbach's α. To determine inter-rater reliability, the concordance correlation coefficient estimated as an intraclass correlation coefficient (CCC) and limits of agreement estimated as the 90% total deviation index (TDI) were estimated. An expert opinion was used to classify patients according to clinical severity. A validity analysis was conducted comparing the 3-level classification score to that expert opinion. Volume under the surface (VUS), predictive values, and probability of correct classification (PCC) were measured to assess discriminant validity.
About 112 patients were recruited, 62 of them (55.4%) males. Median age: 52.5 days (IQR: 32.75-115.25). The admission Cronbach's α was 0.77 (CI95%: 0.71; 0.82) and at 24 hr it was 0.65 (CI95%: 0.48; 0.7). The inter-rater reliability analysis was: CCC at admission 0.96 (95%CI 0.94-0.97), at 24 h 0.77 (95%CI 0.65-0.86), and at 48 hr 0.94 (95%CI 0.94-0.97); TDI 90%: 1.6, 2.9, and 1.57, respectively. The discriminant validity at admission: VUS of 0.8 (95%CI 0.70-0.90), at 24 h 0.92 (95%CI 0.85-0.99), and at 48 hr 0.93 (95%CI 0.87-0.99). The predictive values and PCC values were within 38-100% depending on the level of clinical severity.
There is a high inter-rater reliability, showing the BROSJOD score to be reliable and valid, even when different observers apply it. Pediatr Pulmonol. 2017;52:533-539. © 2016 Wiley Periodicals, Inc.
验证圣琼·德乌儿童医院细支气管炎评分(BROSJOD)并检查先前定义的评分临界值。
前瞻性观察性研究。BROSJOD评分由两名独立的医生进行(入院时、24小时和48小时)。使用Cronbach's α评估评分的内部一致性。为确定评分者间信度,估计作为组内相关系数(CCC)的一致性相关系数以及作为90%总偏差指数(TDI)的一致性界限。采用专家意见根据临床严重程度对患者进行分类。进行有效性分析,将三级分类评分与专家意见进行比较。测量表面下面积(VUS)、预测值和正确分类概率(PCC)以评估判别效度。
共招募了约112名患者,其中62名(55.4%)为男性。中位年龄:52.5天(四分位间距:32.75 - 115.25)。入院时Cronbach's α为0.77(95%置信区间:0.71;0.82),24小时时为0.65(95%置信区间:0.48;0.7)。评分者间信度分析结果为:入院时CCC为0.96(95%置信区间0.94 - 0.97),24小时时为0.77(95%置信区间0.65 - 0.86),48小时时为0.94(95%置信区间0.94 - 0.97);TDI 90%分别为1.6、2.9和1.57。入院时的判别效度:VUS为0.8(95%置信区间0.70 - 0.90),24小时时为0.92(95%置信区间0.85 - 0.99),48小时时为0.93(95%置信区间0.87 - 0.99)。预测值和PCC值根据临床严重程度水平在38% - 100%之间。
评分者间信度较高,表明即使不同观察者应用BROSJOD评分,该评分也是可靠且有效的。《儿科肺病学》。2017年;52:533 - 539。© 2016威利期刊公司。