N-苯基乙酰氨基亚甲基-DL-对硝基苯丙氨酸（A-101）对鼠白血病病毒的抗病毒作用。
Antiviral effect of N-phenylacetoaminomethylene-DL-p-nitrophenylalanine (A-101) on murine leukemia viruses.
作者信息
Fujita H, Sakurai T, Toyoshima S
出版信息
J Natl Cancer Inst. 1979 Mar;62(3):565-8. doi: 10.1093/jnci/62.3.565.
PMID:283285
Abstract
N-Phenylacetoaminomethylene-DL-p-nitrophenylalanine (A-101), when administered ip to male DDY mice infected with Friend leukemia virus, significantly inhibited virus-induced splenomegaly, reduced viable virus titers in spleen and plasma, and significantly prolonged survival time. A-101 also inhibited multiplication of the Friend and Moloney viruses in tissue culture systems.
摘要
N-苯基乙酰氨基亚甲基-DL-对硝基苯丙氨酸（A-101）腹腔注射给予感染弗瑞德白血病病毒的雄性DDY小鼠时，可显著抑制病毒诱导的脾肿大，降低脾脏和血浆中的活病毒滴度，并显著延长存活时间。A-101还可抑制弗瑞德病毒和莫洛尼病毒在组织培养系统中的增殖。
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