Sidwell R W, Allen L B, Huffman J H, Witkowski J T, Sinon L N
Proc Soc Exp Biol Med. 1975 Mar;148(3):854-8. doi: 10.3181/00379727-148-38647.
Ribavirin, when administered intraperitoneally to mice infected with Friend leukemia virus, significantly inhibited development of the disease as determined by inhibition of virus-induced splenomegaly and viable virus titers in the spleen and plasma of the infected animals. The drug was effective whether administered ip in multiple daily treatments, treatments every three days, or single injection. Greatest efficacy was seen when therapy began early in the infection, presumably while the virus was in its eclipse phase.
当给感染了弗瑞德白血病病毒的小鼠腹腔注射利巴韦林时，通过抑制病毒诱导的脾肿大以及感染动物脾脏和血浆中的活病毒滴度来确定，该药物能显著抑制疾病的发展。无论每日多次腹腔注射、每三天注射一次还是单次注射，该药物均有效。当在感染早期开始治疗时，可能是在病毒处于隐蔽期时，观察到了最大疗效。
