口服葡萄糖耐量试验诱导的高血糖会降低儿童血浆而非血清中脑源性神经营养因子的浓度。
Plasma but not serum brain-derived neurotrophic factor concentration is decreased by oral glucose tolerance test-induced hyperglycemia in children.
作者信息
Araki Shunsuke, Yamamoto Yukiyo, Saito Reiko, Kawakita Aoi, Eguchi Mami, Goto Motohide, Kubo Kazuyasu, Kawagoe Rinko, Kawada Yasusada, Kusuhara Koichi
出版信息
J Pediatr Endocrinol Metab. 2017 May 1;30(5):525-530. doi: 10.1515/jpem-2016-0344.
BACKGROUND
Little is known regarding the relationships among circulating brain-derived neurotrophic factor (BDNF) levels and glucose or insulin in children and adolescents. The objective of this study was to investigate whether circulating BDNF levels would change during the oral glucose tolerance test (OGTT).
METHODS
We performed the OGTT and measured the serial changes in BDNF levels in both plasma and serum.
RESULTS
There were 22 subjects in the normal type (N) group and 20 in the borderline/diabetic type (B/D) group, defined by the results of the OGTT. Serum levels of BDNF were almost five times higher and plasma levels gradually decreased during the OGTT, whereas serum levels showed no significant change. The reduction of plasma BDNF level changes from baseline to 120 min were significantly different between the N and B/D groups (36.3% vs. 20.8%, p=0.023).
CONCLUSIONS
Our results showed that plasma levels of BDNF are more sensitive to acute changes in glucose or insulin levels than serum.
背景
关于儿童和青少年循环脑源性神经营养因子（BDNF）水平与葡萄糖或胰岛素之间的关系，人们了解甚少。本研究的目的是调查在口服葡萄糖耐量试验（OGTT）期间循环BDNF水平是否会发生变化。
方法
我们进行了OGTT，并测量了血浆和血清中BDNF水平的系列变化。
结果
根据OGTT结果，正常类型（N）组有22名受试者，边缘/糖尿病类型（B/D）组有20名受试者。在OGTT期间，血清BDNF水平几乎高出五倍，血浆水平逐渐下降，而血清水平无显著变化。N组和B/D组从基线到120分钟血浆BDNF水平变化的降低存在显著差异（36.3%对20.8%，p=0.023）。
结论
我们的结果表明，与血清相比，血浆BDNF水平对葡萄糖或胰岛素水平的急性变化更敏感。
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