口服葡萄糖耐量试验后脑源性神经营养因子与中心脉压的关系。

The association between brain-derived neurotrophic factor and central pulse pressure after an oral glucose tolerance test.

机构信息

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan; School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan; School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.

Cardiovascular Research Center, National Yang-Ming University, Taipei 11221, Taiwan.

出版信息

Clin Chim Acta. 2018 Jan;476:1-8. doi: 10.1016/j.cca.2017.10.023. Epub 2017 Nov 10.

DOI:10.1016/j.cca.2017.10.023

PMID:29080692

Abstract

BACKGROUND

Arterial stiffening blunts postprandial vasodilatation. We hypothesized that brain-derived neurotrophic factor (BDNF) may modulate postprandial central pulse pressure, a surrogate marker for arterial stiffening.

METHODS

A total of 82 non-diabetic subjects received a 75-g oral glucose tolerance test (OGTT) after overnight fasting. Serum BDNF concentrations were determined at 0, 30, and 120min to calculate the area under the curve (AUC). Brachial and central blood pressures were measured using a noninvasive central blood pressure monitor before blood withdrawals at 0 and 120min.

RESULTS

With the median AUC of BDNF of 45(ng/ml)∗h as the cutoff value, the central pulse pressure after glucose intake was significantly higher in the subjects with a low BDNF than in those with a high BDNF (63±16 vs. 53±11mmHg, P=0.003), while the brachial pulse pressure was not significantly different between the 2 groups (P=0.099). In a multivariate linear regression model, a lower AUC of BDNF was an independent predictor of a higher central pulse pressure after oral glucose intake (linear regression coefficient-0.202, 95% confidence interval-0.340 to -0.065, P=0.004).

CONCLUSION

After oral glucose challenge, a lower serum BDNF response is significantly associated with a higher central pulse pressure.

摘要

背景

动脉僵硬会使餐后血管舒张减弱。我们假设脑源性神经营养因子（BDNF）可能调节餐后中心脉压，这是动脉僵硬的替代标志物。

方法

共 82 名非糖尿病受试者在隔夜禁食后接受 75g 口服葡萄糖耐量试验（OGTT）。在 0、30 和 120 分钟时测定血清 BDNF 浓度，以计算曲线下面积（AUC）。在 0 和 120 分钟采血前，使用无创中心血压监测仪测量肱动脉和中心血压。

结果

以 BDNF 的 AUC 中位数为 45（ng/ml）∗h 作为截断值，与高 BDNF 相比，低 BDNF 受试者餐后中心脉压明显升高（63±16 与 53±11mmHg，P=0.003），而两组间肱动脉脉压无显著差异（P=0.099）。在多元线性回归模型中，BDNF 的 AUC 较低是口服葡萄糖摄入后中心脉压升高的独立预测因子（线性回归系数-0.202，95%置信区间-0.340 至-0.065，P=0.004）。