Cardy R H, Renne R A, Warner J W, Cypher R L
J Natl Cancer Inst. 1979 Mar;62(3):569-78. doi: 10.1093/jnci/62.3.569.
The insecticide synergist piperonyl butoxide--alpha-[2-(2-butoxyethoxy)ethoxy]-4,5-methylenedioxy-2-propyltoluene--was tested for carcinogenicity in inbred F344 rats in a 2-year study employing doses of 10,000 and 5,000 ppm of the compound administered continuously in the feed. Although a statistically significant dose-related increase in the incidence of lymphoreticular neoplasia was associated with administration of the compound to females, the incidence of that class of neoplasm was higher in control males than in treated males. The finding of statistical significance in one sex is not considered by itself to constitute sufficient evidence of a biologic effect to justify an indictment of carcinogenic action. However, inasmuch as the chief use of this substance is to alter the in vivo metabolism of other chemicals, its possible role as a cocarcinogen should be carefully considered in any risk-benefit evaluation aimed at setting policies regarding its uses.
杀虫剂增效剂胡椒基丁醚（α-[2-(2-丁氧基乙氧基)乙氧基]-4,5-亚甲基二氧基-2-丙基甲苯）在一项为期两年的研究中，以10000 ppm和5000 ppm的剂量持续添加到饲料中，对近交系F344大鼠进行致癌性测试。虽然给雌性大鼠施用该化合物后，淋巴网状细胞瘤的发病率出现了与剂量相关的统计学显著增加，但该类肿瘤在对照雄性大鼠中的发病率高于经处理的雄性大鼠。仅在一种性别中发现统计学显著性，本身并不被认为足以构成生物学效应的充分证据，以证明致癌作用的指控。然而，鉴于该物质的主要用途是改变其他化学物质的体内代谢，在任何旨在制定其使用政策的风险效益评估中，都应仔细考虑其作为促癌剂的可能作用。
