Maekawa A, Onodera H, Furuta K, Tanigawa H, Ogiu T, Hayashi Y
Food Chem Toxicol. 1985 Jul;23(7):675-82. doi: 10.1016/0278-6915(85)90156-5.
The carcinogenicity of technical-grade piperonyl butoxide was studied in F344/DuCrj rats fed a dietary level of 0.5 or 1% for 2 yr. Various tumours were detected in all groups, including the untreated control group, but no significant dose-related increase in the incidence of any tumour was found. Thus, it is concluded that under these experimental conditions piperonyl butoxide was not carcinogenic in F344 rats. Unexpectedly, however, ileocaecal ulcers were found in animals of both sexes in both experimental groups and the incidence was dose related. Further studies are required to establish the mechanism of induction of ileocaecal ulcers by piperonyl butoxide.
研究了技术级胡椒基丁醚在饮食中添加0.5%或1%的情况下对F344/DuCrj大鼠进行为期2年的致癌性。在所有组中都检测到了各种肿瘤，包括未处理的对照组，但未发现任何肿瘤的发生率有显著的剂量相关增加。因此，得出结论，在这些实验条件下，胡椒基丁醚对F344大鼠无致癌性。然而，出乎意料的是，在两个实验组的雌雄动物中均发现了回盲部溃疡，且发生率与剂量相关。需要进一步研究以确定胡椒基丁醚诱导回盲部溃疡的机制。
