Romanowski Kathleen S, Fagin Alice, Werling Bridget, Kass Gretchen, Liao Junlin, Granchi Thomas, Kealey Gerald P, Wibbenmeyer Lucy
From the *Department of Surgery, University of Iowa; †Department of Surgery, University of Arkansas and Arkansas Children's Hospital, Little Rock; and ‡Department of Nursing, University of Iowa.
J Burn Care Res. 2017 Nov/Dec;38(6):365-370. doi: 10.1097/BCR.0000000000000531.
Hidradenitis suppurativa (HS) is a debilitating suppurative disease of the apocrine/follicular glands. Medical treatment has some efficacy in early-stage disease but is costly and requires frequent physician visits. Advanced disease usually requires surgical intervention. This treatment has not been well described in the literature. We sought to review our experience with HS treatment in a large surgical cohort. A retrospective review of 98 consecutive HS patients from 2000 to 2014 was performed. A two-stage operative approach was used. The first stage involved the removal of all the hair-bearing skin in the affected areas down to healthy tissue followed by the application of split-thickness skin grafts 48 to 72 hours later. Descriptive statistics were performed to describe the population and assess outcomes. The study population was young (36 ± 12 years) and predominately female (65, 66%). The patients were obese (body mass index, 36 ± 8.3 kg/m) and smokers (73, 73.7%). The majority presented with axillary disease (73%). There were 144 debridement procedures and 146 grafting procedures performed with a mean area grafted being 416 ± 500 cm (90-3400 cm). Only nine (9%) required regrafting, with the mean area regrafted being 140 ± 93 cm. Graft failure of less than 30% did not require regrafting. At 30 days after the initial procedure, 94.7% of all wounds were fully grafted and closed. Advanced stages of HS require ablation of the infected distorted glands for control of recurrent infections. Ablative excision of HS-affected skin and wound closure with split-thickness skin grafts is a safe, reliable, and effective therapy.
化脓性汗腺炎(HS)是一种累及顶泌汗腺/毛囊腺的致残性化脓性疾病。药物治疗在疾病早期有一定疗效,但费用高昂且需要频繁就医。晚期疾病通常需要手术干预。这种治疗方法在文献中尚未得到充分描述。我们试图回顾我们在一个大型外科队列中治疗HS的经验。对2000年至2014年连续98例HS患者进行了回顾性研究。采用两阶段手术方法。第一阶段包括切除受累区域所有有毛发的皮肤直至健康组织,48至72小时后进行中厚皮片移植。进行描述性统计以描述研究人群并评估结果。研究人群年轻(36±12岁),以女性为主(65例,66%)。患者肥胖(体重指数,36±8.3kg/m)且吸烟(73例,73.7%)。大多数患者表现为腋窝疾病(73%)。共进行了144次清创手术和146次移植手术,平均移植面积为416±500cm²(90 - 3400cm²)。只有9例(9%)需要再次移植,平均再次移植面积为140±93cm²。移植失败率低于30%的患者不需要再次移植。在初次手术后30天,所有伤口中有94.7%完全移植并愈合。HS的晚期需要切除受感染变形的腺体以控制反复感染。切除受HS影响的皮肤并用中厚皮片闭合伤口是一种安全、可靠且有效的治疗方法。