Troup Lucy J, Torrence Robert D, Andrzejewski Jeremy A, Braunwalder Jacob T
Colorado State University, Fort Collins, Colorado.
Medicine (Baltimore). 2017 Mar;96(12):e6385. doi: 10.1097/MD.0000000000006385.
The effects of residual cannabis use on emotional expression recognition and the P3 event-related potential in participants who scored highly for subclinical depression were investigated. Comparisons were made between participants who were classified as depressed or nondepressed cannabis users, depressed non-cannabis users and controls who neither used cannabis nor were characterized as being depressed. In an emotional expression recognition task, participants were asked to respond to faces depicting happy, angry, fearful, and neutral faces either implicitly, explicitly, or empathically. Residual cannabis use and mood was shown to modulate the P3 event related potential during the task. There was a significant reduction in the P3 amplitude between depressed and nondepressed participants. Residual cannabis use further reduced the P3 amplitude with the greatest deficits being associated with cannabis users who scored highly for subclinical depression. These effects were greatest for explicit and empathic processing of faces depicting negative emotions. We conclude from our study that cannabis and mood state interact to reduce the amplitude of the P3 which has been associated with attention to emotion.
研究了残留大麻使用对亚临床抑郁症得分较高的参与者的情绪表达识别和P3事件相关电位的影响。对被分类为抑郁或非抑郁大麻使用者、抑郁非大麻使用者以及既不使用大麻也未被归类为抑郁的对照组参与者进行了比较。在一项情绪表达识别任务中，要求参与者以隐含、明确或共情的方式对描绘快乐、愤怒、恐惧和中性表情的面孔做出反应。结果显示，残留大麻使用和情绪在任务过程中调节了P3事件相关电位。抑郁和非抑郁参与者之间的P3波幅显著降低。残留大麻使用进一步降低了P3波幅，最大的缺陷与亚临床抑郁症得分较高的大麻使用者相关。这些影响在对面孔的明确和共情处理中最为明显，这些面孔描绘了负面情绪。我们从研究中得出结论，大麻和情绪状态相互作用，降低了与情绪注意力相关的P3波幅。
