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根据欧洲心脏病学会急性冠状动脉综合征质量指标评估医院表现及急性心肌梗死的30天死亡率:使用英国心肌缺血国家审计项目(MINAP)登记册的全国队列研究

Performance of hospitals according to the ESC ACCA quality indicators and 30-day mortality for acute myocardial infarction: national cohort study using the United Kingdom Myocardial Ischaemia National Audit Project (MINAP) register.

作者信息

Bebb Owen, Hall Marlous, Fox Keith A A, Dondo Tatendashe B, Timmis Adam, Bueno Hector, Schiele François, Gale Chris P

机构信息

Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.

York Teaching Hospital NHS Foundation Trust, York, UK.

出版信息

Eur Heart J. 2017 Apr 1;38(13):974-982. doi: 10.1093/eurheartj/ehx008.

Abstract

AIMS

To investigate the application of the European Society of Cardiology Acute Cardiovascular Care Association quality indicators (QI) for acute myocardial infarction for the study of hospital performance and 30-day mortality.

METHODS AND RESULTS

National cohort study (n = 118,075 patients, n = 211 hospitals, MINAP registry), 2012-13. Overall, 16 of the 20 QIs could be calculated. Eleven QIs had a significant inverse association with GRACE risk adjusted 30-day mortality (all P < 0.005). The association with the greatest magnitude was high attainment of the composite opportunity-based QI (80-100%) vs. zero attainment (odds ratio 0.04, 95% confidence interval 0.04-0.05, P < 0.001), increasing attainment from low (0.42, 0.37- 0.49, P < 0.001) to intermediate (0.15, 0.13-0.16, P < 0.001) was significantly associated with a reduced risk of 30-day mortality. A 1% increase in attainment of this QI was associated with a 3% reduction in 30-day mortality (0.97, 0.97-0.97, P < 0.001). The QI with the widest hospital variation was 'fondaparinux received among NSTEMI' (interquartile range 84.7%) and least variation 'centre organisation' (0.0%), with seven QIs depicting minimal variation (<11%). GRACE risk score adjusted 30-day mortality varied by hospital (median 6.7%, interquartile range 5.4-7.9%).

CONCLUSIONS

Eleven QIs were significantly inversely associated with 30-day mortality. Increasing patient attainment of the composite quality indicator was the most powerful predictor; a 1% increase in attainment represented a 3% decrease in 30-day standardised mortality. The ESC QIs for acute myocardial infarction are applicable in a large health system and have the potential to improve care and reduce unwarranted variation in death from acute myocardial infarction.

摘要

目的

探讨欧洲心脏病学会急性心血管护理协会急性心肌梗死质量指标(QI)在医院绩效和30天死亡率研究中的应用。

方法与结果

2012 - 2013年全国队列研究(n = 118,075例患者,n = 211家医院,MINAP注册登记)。总体而言,20个质量指标中的16个可以计算。11个质量指标与GRACE风险调整后的30天死亡率呈显著负相关(所有P < 0.005)。关联程度最大的是基于机会的综合质量指标高达成率(80 - 100%)与零达成率相比(优势比0.04,95%置信区间0.04 - 0.05,P < 0.001),达成率从低水平(0.42,0.37 - 0.49,P < 0.001)增加到中等水平(0.15,0.13 - 0.16,P < 0.001)与30天死亡率风险降低显著相关。该质量指标达成率每增加1%与30天死亡率降低3%相关(0.97,0.97 - 0.97,P < 0.001)。医院差异最大的质量指标是“非ST段抬高型心肌梗死患者接受磺达肝癸钠治疗”(四分位间距84.7%),差异最小的是“中心组织”(0.0%),7个质量指标显示差异极小(<11%)。GRACE风险评分调整后的30天死亡率因医院而异(中位数6.7%,四分位间距5.4 - 7.9%)。

结论

11个质量指标与30天死亡率显著负相关。患者对综合质量指标达成率的提高是最有力的预测因素;达成率每增加1%代表30天标准化死亡率降低3%。欧洲心脏病学会急性心肌梗死质量指标适用于大型医疗系统,有可能改善护理并减少急性心肌梗死死亡中不必要的差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01a5/5724351/98fa9d22f3d2/ehx008f1.jpg

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