Wu I-Chien, Lin Cheng-Chieh, Liu Chin-San, Hsu Chih-Cheng, Chen Ching-Yu, Hsiung Chao A
Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, Taiwan.
Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.
J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):937-944. doi: 10.1093/gerona/glx033.
Interplays between inflammation and mitochondrial biology are reported. Here, we examined the cross-sectional interrelationships of mitochondrial DNA copy number (mtDNACN) and inflammation and their interaction with physical functioning.
A total of 1990 community-dwelling adults aged 65 years and older who were participating in the Healthy Aging Longitudinal Study in Taiwan underwent measurements of peripheral-blood leukocytes MtDNACN, multiple inflammatory markers, grip strength, and gait speed.
Principal components analysis revealed two inflammatory factors: factor 1 (high-sensitivity C-reactive protein [hs-CRP], white blood cell count, fibrinogen and interleukin-6 [IL-6]); factor 2 (tumor necrosis factor receptor 1, D-dimer and soluble interleukin-6 receptor). Participants with severe physical functioning impairment (low grip strength and gait speed) had higher (p < .05) levels of factor 1 and 2, but not mtDNACN, than did those with moderately impaired (low grip strength or gait speed) and normal physical functioning. MtDNACN was negatively related to factor 1 (r = -.221, p < .001) but not factor 2 (r = -.002, p = .938). Increased factor 1 was strongly associated with higher odds of physical functioning impairment in those with a low mtDNACN (adjusted odds ratios [OR] of moderate physical function impairment 1.21, 95% CI 1.01-1.44; adjusted OR of severe physical function impairment 1.52, 95% CI 1.25-1.85) but not in those with a high mtDNACN (p for interaction = .016).
A low mtDNACN was associated with an inflammation exhibiting elevated hs-CRP, IL-6, fibrinogen, and white blood cell count, and strengthened the association of this inflammation with physical functioning impairment.
据报道，炎症与线粒体生物学之间存在相互作用。在此，我们研究了线粒体DNA拷贝数（mtDNACN）与炎症的横断面相互关系及其与身体功能的相互作用。
共有1990名年龄在65岁及以上、参与台湾健康老龄化纵向研究的社区居民接受了外周血白细胞MtDNACN、多种炎症标志物、握力和步速的测量。
主成分分析揭示了两种炎症因子：因子1（高敏C反应蛋白[hs-CRP]、白细胞计数、纤维蛋白原和白细胞介素-6[IL-6]）；因子2（肿瘤坏死因子受体1、D-二聚体和可溶性白细胞介素-6受体）。与身体功能中度受损（握力或步速低）和身体功能正常的参与者相比，身体功能严重受损（握力和步速低）的参与者因子1和因子2水平更高（p <.05），但mtDNACN水平并非如此。MtDNACN与因子1呈负相关（r = -.221，p <.001），但与因子2无相关性（r = -.002，p =.938）。因子1升高与mtDNACN低的人群身体功能受损的较高几率密切相关（中度身体功能受损的调整优势比[OR]为1.21，95%CI为1.01-1.44；严重身体功能受损的调整OR为1.52，95%CI为1.25-1.85），而在mtDNACN高的人群中则不然（交互作用p =.016）。
低mtDNACN与hs-CRP、IL-6、纤维蛋白原和白细胞计数升高的炎症相关，并加强了这种炎症与身体功能受损之间的关联。
