The Department of Family Medicine, Changhua Christian Hospital, Changhua, Taiwan.
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Aging (Albany NY). 2021 Apr 4;13(7):10555-10583. doi: 10.18632/aging.202820.
Uric acid is both a pro-oxidant and antioxidant. We investigated serum uric acid's association with mortality and aging biomarkers in older adults with varying levels of grip strength. A total of 5329 community-dwelling adults aged ≥55 years underwent assessments of serum uric acid levels, grip strength, and biomarkers of diverse physiological systems. The primary outcome was all-cause mortality. We observed a significant (P < .001) interaction between uric acid levels and grip strength on all-cause mortality risk. Among participants with low grip strength, a nonlinear association (P for nonlinearity = .006) was observed between serum uric acid levels and mortality risk after multivariate adjustment. Compared with participants with neither extreme uric acid levels nor low grip strength, those with a combination of high serum uric acid and low grip strength exhibited greater risks of mortality (adjusted hazard ratio [aHR], 1.52; 95% confidence interval [CI], 1.15-2.02) and deviations in biomarkers of specific systems, so did those with a combination of low serum uric acid and low grip strength (aHR, 1.52; 95% CI, 1.13-2.05). In conclusion, there was a J-shaped association between serum uric acid and the risk of all-cause mortality in older adults. This was primarily true for those with low grip strength.
尿酸既是一种促氧化剂又是一种抗氧化剂。我们研究了血清尿酸与握力不同的老年人死亡率和衰老生物标志物的关系。共有 5329 名年龄≥55 岁的社区居住成年人接受了血清尿酸水平、握力和多种生理系统生物标志物的评估。主要结局是全因死亡率。我们观察到尿酸水平和握力对全因死亡率风险之间存在显著（P<.001）的交互作用。在握力较弱的参与者中，在进行多变量调整后，观察到血清尿酸水平与死亡率风险之间存在非线性关联（非线性检验 P<.006）。与既没有极端尿酸水平也没有握力较弱的参与者相比，同时具有高血清尿酸和低握力的参与者的死亡率风险更高（调整后的危险比[aHR]，1.52；95%置信区间[CI]，1.15-2.02），特定系统生物标志物也存在偏差，同时具有低血清尿酸和低握力的参与者也是如此（aHR，1.52；95%CI，1.13-2.05）。总之，血清尿酸与老年人全因死亡率风险之间存在 J 形关联。对于握力较弱的人来说，这种关联更为明显。
