Zhang Z X, Zhang Y Z, Jia S P, Lu X J, Yu R R, Wang X G, Chen R S
Division of Physiology, Department of Biology, Nanjing Unviversity.
Sci Sin B. 1987 Sep;30(9):974-85.
Role of brain Ca2+ in electro-acupuncture analgesia and the development of analgesic tolerance to electro-acupuncture and morphine were studied. At the same time, the inhibition by protein synthesis inhibitors of the development of analgesic tolerance to electro-acupuncture was observed. The results showed that like morphine tolerance, the brain Ca2+ and cAMP levels in mice were enhanced with the development of analgesic tolerance to electro-acupuncture. After treatment with protein synthesis inhibitors anisomycin, actinomycin or cycloheximide the development of analgesic tolerance to electro-acupuncture was inhibited, and concurrently, the brain Ca2+ and cAMP levels in the animals greatly reduced. From the changes of brain Ca2+ and cAMP levels, the analgesic effects by electro-acupuncture, morphine and lanthanides seem to be very similar and share a mutual ion basis and the mechanism of action. So does the development of analgesic tolerance to electro-acupuncture and morphine. These findings also suggest that the inhibition induced by the inhibitors of the analgesic tolerance to electro-acupuncture and morphine may be related to synthesis of new peptides or RNA in brain.
研究了脑内钙离子在电针镇痛及对电针和吗啡镇痛耐受性形成中的作用。同时，观察了蛋白质合成抑制剂对电针镇痛耐受性形成的抑制作用。结果表明，与吗啡耐受性相似，随着电针镇痛耐受性的形成，小鼠脑内钙离子和环磷酸腺苷（cAMP）水平升高。用蛋白质合成抑制剂茴香霉素、放线菌素或环己酰亚胺处理后，电针镇痛耐受性的形成受到抑制，同时，动物脑内钙离子和cAMP水平大幅降低。从脑内钙离子和cAMP水平的变化来看，电针、吗啡和镧系元素的镇痛作用似乎非常相似，具有共同的离子基础和作用机制。电针和吗啡镇痛耐受性的形成也是如此。这些发现还表明，抑制剂对电针和吗啡镇痛耐受性的抑制作用可能与脑内新肽或核糖核酸（RNA）的合成有关。
