Howard Hannah E, Zwerner Jeffrey P, Byers Jeffrey, Tkaczyk Eric
University of Oklahoma, Department of Dermatology, Oklahoma City, OK.
Dermatol Online J. 2016 Oct 15;22(10):13030/qt1gf1h3xm.
We report the case of a 44-year-old woman with a history of Crohn disease treated with infliximab who presented with erythematous papules and plaques on the upper extremities accompanied by fevers. She was subsequently diagnosed with palisaded neutrophilic and granulomatous dermatitis (PNGD). Whereas immune-complex mediated diseases such as rheumatoid arthritis and systemic lupus erythematosus are most commonly associated, inflammatory bowel disease deserves increased consideration as one of the systemic diseases that can present with PNGD. Additionally, PNGD should remain in the differential diagnosis of cutaneous eruptions that develop in the setting of tumor necrosis factor (TNF) antagonist therapy.
我们报告了一例44岁患有克罗恩病且接受英夫利昔单抗治疗的女性病例，该患者上肢出现红斑丘疹和斑块并伴有发热。她随后被诊断为栅栏状中性粒细胞和肉芽肿性皮炎（PNGD）。虽然类风湿关节炎和系统性红斑狼疮等免疫复合物介导的疾病是最常见的相关疾病，但炎症性肠病作为可能出现PNGD的全身性疾病之一，应得到更多关注。此外，PNGD应保留在肿瘤坏死因子（TNF）拮抗剂治疗背景下发生的皮肤疹的鉴别诊断中。
