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与脂肪肝疾病和假性胰高血糖素瘤综合征相关的坏死性游走性红斑

Necrolytic migratory erythema associated with fatty liver disease and the psuedoglucagonoma syndrome.

作者信息

Fuller Collin, Glick Jaimie, Rivas Shelly, Burris Katy

机构信息

Hofstra Northwell School of Medicine, Department of Dermatology, Hempstead.

出版信息

Dermatol Online J. 2016 Sep 15;22(9):13030/qt8108d88h.

PMID:28329615
Abstract

We report a 48-year-old woman with a past medical history of psoriasis, nonalcoholic steatohepatitis (NASH), and type II diabetes mellitus, who presented to the emergency department with a 1 week history of erosive annular plaques with associated atrophy and telangiectasias on her legs bilaterally, thighs and buttock, histopathologically consistent with necrolytic migratory erythema. Although classically associated with a pancreatic glucagonoma, this patient experienced this figurate erythema in the setting of fatty liver disease with no glucagonoma. The rarity of pseudoglucagonoma syndrome, or necrolytic migratory erythema occurring in the absence of a glucagonoma, warranted the discussion of this case.

摘要

我们报告一名48岁女性,既往有银屑病、非酒精性脂肪性肝炎(NASH)和II型糖尿病病史,她因双侧腿部、大腿和臀部出现糜烂性环状斑块伴萎缩和毛细血管扩张1周就诊于急诊科,组织病理学检查结果与坏死松解性游走性红斑一致。虽然经典的坏死松解性游走性红斑与胰腺高血糖素瘤相关,但该患者在无高血糖素瘤的脂肪性肝病背景下出现了这种形态的红斑。假性高血糖素瘤综合征,即无高血糖素瘤时发生的坏死松解性游走性红斑非常罕见,因此有必要对该病例进行讨论。

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